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Md Dom S, Abdul Razak HR, Ahmad Zaiki FW, et al. Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level. Quant Imaging Med Surg. 2013;3(1):49-53doi: 10.3978/j.issn.2223-4292.2013.02.06.
Md Dom, S., Abdul Razak, H. R., Ahmad Zaiki, F. W., Saat, N. H., Abd Manan, K., Che Isa, I. N., & Hashim, U. F. (2013). Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level. Quantitative imaging in medicine and surgery, 3(1), 49-53. https://doi.org/10.3978/j.issn.2223-4292.2013.02.06
Md Dom, Sulaiman, et al. "Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level." Quantitative imaging in medicine and surgery vol. 3,1 (2013): 49-53. doi: https://doi.org/10.3978/j.issn.2223-4292.2013.02.06
Md Dom S, Abdul Razak HR, Ahmad Zaiki FW, Saat NH, Abd Manan K, Che Isa IN, Hashim UF. Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level. Quant Imaging Med Surg. 2013 Feb;3(1):49-53. doi: 10.3978/j.issn.2223-4292.2013.02.06. PMID: 23483040; PMCID: PMC3591501.
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Quant Imaging Med Surg. 2013 Feb;3(1):49-53. doi: 10.3978/j.issn.2223-4292.2013.02.06.

Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level.

Quantitative imaging in medicine and surgery

Sulaiman Md Dom, Hairil Rashmizal Abdul Razak, Farah Wahida Ahmad Zaiki, Nurul Hidayah Saat, Khairunnisa Abd Manan, Iza Nurzawani Che Isa, Ummi Farhana Hashim

Affiliations

  1. Universiti Teknologi MARA, Selangor, Malaysia;

PMID: 23483040 PMCID: PMC3591501 DOI: 10.3978/j.issn.2223-4292.2013.02.06

Abstract

The aim of this study was to investigate the changes in parathyroid hormone (PTH) level of rabbit foetal bodies exposed to ultrasound at different gestational stages. A total of 9 pregnant rabbits (Oryctolagus cuniculus) were insonated for 60 minutes at the middle of 1(st), 2(nd) and 3(rd) gestational stages for group A (n=14 newborns), group B (n=7 newborns) and group C (n=24 newborns) respectively. Seven pregnant rabbits with 41 newborns severed as negative control group. Blood samples were withdrawn from each newborn rabbits for Parathyroid Hormone-Intact (PTH-I) test. Results of the independent samples t-test implied statistically significant differences (P<0.05) between the control group and the 1(st) stage (P=0.001), the 2(nd) stage (P<0.001) and the 3(rd) stage group (P<0.001). This in-vivo study revealed diagnostic ultrasound heating has the potential of affecting foetal PTH level. This study observed significantly low PTH level for all the treated groups. A further study should be instituted to determine whether this finding in rabbit may also occur in human by means of clinical trials.

Keywords: Ultrasound imaging; parathyroid hormone; parathyroid hormone-intact test

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