Display options
Cite
Grandoni K, Gentry P, Holub B, et al. Comparative effects of trichothecene mycotoxins on bovine platelet function: Acetyl T-2 toxin, a more potent inhibitor than T-2 toxin. Mycotoxin Res. 1990;6(2):61-6doi: 10.1007/BF03192144.
Grandoni, K., Gentry, P., Holub, B., & Yagen, B. (1990). Comparative effects of trichothecene mycotoxins on bovine platelet function: Acetyl T-2 toxin, a more potent inhibitor than T-2 toxin. Mycotoxin research, 6(2), 61-6. https://doi.org/10.1007/BF03192144
Grandoni, K, et al. "Comparative effects of trichothecene mycotoxins on bovine platelet function: Acetyl T-2 toxin, a more potent inhibitor than T-2 toxin." Mycotoxin research vol. 6,2 (1990): 61-6. doi: https://doi.org/10.1007/BF03192144
Grandoni K, Gentry P, Holub B, Yagen B. Comparative effects of trichothecene mycotoxins on bovine platelet function: Acetyl T-2 toxin, a more potent inhibitor than T-2 toxin. Mycotoxin Res. 1990 Sep;6(2):61-6. doi: 10.1007/BF03192144. PMID: 23605444.
Copy Download .nbib Format: NLM
Share it on

Mycotoxin Res. 1990 Sep;6(2):61-6. doi: 10.1007/BF03192144.

Comparative effects of trichothecene mycotoxins on bovine platelet function: Acetyl T-2 toxin, a more potent inhibitor than T-2 toxin.

Mycotoxin research

K Grandoni, P Gentry, B Holub, B Yagen

Affiliations

  1. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, N1G 2W1 ; (519) 824-4120, Guelph, Ontario, Canada.

PMID: 23605444 DOI: 10.1007/BF03192144

Abstract

The effects of the trichothecene mycotoxins (acetyl T-2 toxin, T-2 toxin, HT-2 toxin, palmityl T-2 toxin, diacetoxyscirpenol (DAS), deoxynivalenol (DON), and T-2 tetraol) on bovine platelet function were examined in homologous plasma stimulated with platelet activating factor (PAF). The mycotoxins inhibited platelet function with the following order of potency: acetyl T-2 toxin > palmityl T-2 toxin = DAS > HT-2 toxin = T-2 toxin. While T-2 tetraol was completely ineffective as an inhibitor, DON exhibited minimal inhibitory activity at concentrations above 10×10(-4)M. The stability of the platelet aggregates formed was significantly reduced in all mycotoxin treated platelets compared to that of the untreated PAF controls. It is suggested that the increased sensitivity of PAF stimulated bovine platelets to the more lipophilic mycotoxins may be related to their more efficient partitioning into the platelet membrane compared to the more hydrophilic compounds.

References

  1. Food Chem Toxicol. 1984 Aug;22(8):643-8 - PubMed
  2. Vet Res Commun. 1987;11(5):457-66 - PubMed
  3. Can J Vet Res. 1987 Oct;51(4):490-4 - PubMed
  4. Toxicol Appl Pharmacol. 1984 Dec;76(3):454-63 - PubMed
  5. Thromb Haemost. 1983 Jun 28;49(3):162-7 - PubMed
  6. Biochim Biophys Acta. 1988 Aug 19;971(1):1-8 - PubMed
  7. Semin Hematol. 1985 Jul;22(3):219-40 - PubMed
  8. Mycotoxin Res. 1988 Mar;4(1):25-32 - PubMed
  9. FEBS Lett. 1983 Mar 21;153(2):361-5 - PubMed
  10. Biochem Pharmacol. 1981 Feb 15;30(4):263-71 - PubMed
  11. Fundam Appl Toxicol. 1989 Jan;12(1):109-16 - PubMed
  12. Prog Lipid Res. 1987;26(1):1-28 - PubMed
  13. Toxicol Appl Pharmacol. 1984 Apr;73(2):210-7 - PubMed
  14. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;92(1):67-72 - PubMed
  15. Toxicol Appl Pharmacol. 1983 Sep 30;70(3):343-9 - PubMed
  16. Toxicol In Vitro. 1989;3(3):175-9 - PubMed
  17. Toxicol Appl Pharmacol. 1988 Jan;92(1):113-21 - PubMed
  18. Appl Environ Microbiol. 1984 Apr;47(4):681-4 - PubMed
  19. Vet Immunol Immunopathol. 1984 Aug;7(1):81-7 - PubMed
  20. Food Chem Toxicol. 1986 Apr;24(4):311-7 - PubMed
  21. J Biol Chem. 1983 Jun 25;258(12):7241-4 - PubMed
  22. Toxicol In Vitro. 1988;2(4):241-5 - PubMed

Publication Types