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Gareis M, Ertl B, Bauer J, et al. Biotransformation of T-2 toxin and diacetoxyscirpenol in the isolated perfused rat liver. Mycotoxin Res. 1985;1(2):77-82doi: 10.1007/BF03192007.
Gareis, M., Ertl, B., Bauer, J., & Gedek, B. (1985). Biotransformation of T-2 toxin and diacetoxyscirpenol in the isolated perfused rat liver. Mycotoxin research, 1(2), 77-82. https://doi.org/10.1007/BF03192007
Gareis, M, et al. "Biotransformation of T-2 toxin and diacetoxyscirpenol in the isolated perfused rat liver." Mycotoxin research vol. 1,2 (1985): 77-82. doi: https://doi.org/10.1007/BF03192007
Gareis M, Ertl B, Bauer J, Gedek B. Biotransformation of T-2 toxin and diacetoxyscirpenol in the isolated perfused rat liver. Mycotoxin Res. 1985 Sep;1(2):77-82. doi: 10.1007/BF03192007. PMID: 23605792.
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Mycotoxin Res. 1985 Sep;1(2):77-82. doi: 10.1007/BF03192007.

Biotransformation of T-2 toxin and diacetoxyscirpenol in the isolated perfused rat liver.

Mycotoxin research

M Gareis, B Ertl, J Bauer, B Gedek

Affiliations

  1. Institute for Medical Microbiology, Infectious and Epidemic Diseases, Faculty of Veterinary Medicine, University of Munich, Veterinärstr. 13, 8000, Munich 22, FRG.

PMID: 23605792 DOI: 10.1007/BF03192007

Abstract

CONCLUSION: Twelve metabolites of T-2 toxin and two metabolites of DAS have been detected by GLC-MS in the perfusate of isolated rat livers. Less than 50% of the administered dose was recovered in the perfusate. However, preliminary results of the analysis of bile show that considerable amounts of T-2 toxin and DAS were excreted mainly as glucuronide conjugates. The concurrence of the data reported here with the results of in vivo studies indicate that the isolaged perfused rat liver system is suitable in studying the metabolism of trichothecence mycotoxins.

References

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