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Ji Y, Mao G, Wang Y, et al. Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases. Front Microbiol. 2013;4:58doi: 10.3389/fmicb.2013.00058.
Ji, Y., Mao, G., Wang, Y., & Bartlam, M. (2013). Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases. Frontiers in microbiology, 458. https://doi.org/10.3389/fmicb.2013.00058
Ji, Yurui, et al. "Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases." Frontiers in microbiology vol. 4 (2013): 58. doi: https://doi.org/10.3389/fmicb.2013.00058
Ji Y, Mao G, Wang Y, Bartlam M. Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases. Front Microbiol. 2013 Mar 21;4:58. doi: 10.3389/fmicb.2013.00058. eCollection 2013. PMID: 23519435; PMCID: PMC3604635.
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Front Microbiol. 2013 Mar 21;4:58. doi: 10.3389/fmicb.2013.00058. eCollection 2013.

Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases.

Frontiers in microbiology

Yurui Ji, Guannan Mao, Yingying Wang, Mark Bartlam

Affiliations

  1. Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University Tianjin, China ; State Key Laboratory of Medicinal Chemical Biology, Nankai University Tianjin, China.

PMID: 23519435 PMCID: PMC3604635 DOI: 10.3389/fmicb.2013.00058

Abstract

Environmental microbes utilize four degradation pathways for the oxidation of n-alkanes. Although the enzymes degrading n-alkanes in different microbes may vary, enzymes functioning in the first step in the aerobic degradation of alkanes all belong to the alkane hydroxylases. Alkane hydroxylases are a class of enzymes that insert oxygen atoms derived from molecular oxygen into different sites of the alkane terminus (or termini) depending on the type of enzymes. In this review, we summarize the different types of alkane hydroxylases, their degrading steps, and compare typical enzymes from various classes with regard to their three-dimensional structures, in order to provide insights into how the enzymes mediate their different roles in the degradation of n-alkanes and what determines their different substrate ranges. Through the above analyzes, the degrading mechanisms of enzymes can be elucidated and molecular biological methods can be utilized to expand their catalytic roles in the petrochemical industry or in bioremediation of oil-contaminated environments.

Keywords: (an)aerobic; AlkB; LadA; alkane hydroxylases; biodegradation mechanism; cytochrome P450; pMMO; sMMO

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