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Donnelly RF, Singh TR, Garland MJ, et al. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery. Adv Funct Mater. 2012;22(23):4879-4890doi: 10.1002/adfm.201200864.
Donnelly, R. F., Singh, T. R., Garland, M. J., Migalska, K., Majithiya, R., McCrudden, C. M., Kole, P. L., Mahmood, T. M., McCarthy, H. O., & Woolfson, A. D. (2012). Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery. Advanced functional materials, 22(23), 4879-4890. https://doi.org/10.1002/adfm.201200864
Donnelly, Ryan F, et al. "Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery." Advanced functional materials vol. 22,23 (2012): 4879-4890. doi: https://doi.org/10.1002/adfm.201200864
Donnelly RF, Singh TR, Garland MJ, Migalska K, Majithiya R, McCrudden CM, Kole PL, Mahmood TM, McCarthy HO, Woolfson AD. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery. Adv Funct Mater. 2012 Dec 05;22(23):4879-4890. doi: 10.1002/adfm.201200864. Epub 2012 Jul 09. PMID: 23606824; PMCID: PMC3627464.
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Adv Funct Mater. 2012 Dec 05;22(23):4879-4890. doi: 10.1002/adfm.201200864. Epub 2012 Jul 09.

Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery.

Advanced functional materials

Ryan F Donnelly, Thakur Raghu Raj Singh, Martin J Garland, Katarzyna Migalska, Rita Majithiya, Cian M McCrudden, Prashant Laxman Kole, Tuan Mazlelaa Tuan Mahmood, Helen O McCarthy, A David Woolfson

Affiliations

  1. School of Pharmacy, Queens University Belfast 97 Lisburn Road, Belfast BT9 7BL, UK.

PMID: 23606824 PMCID: PMC3627464 DOI: 10.1002/adfm.201200864

Abstract

Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed completely intact from the skin. Delivery of macromolecules is no longer limited to what can be loaded into the microneedles themselves and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. This technology has the potential to overcome the limitations of conventional microneedle designs and greatly increase the range of the type of drug that is deliverable transdermally, with ensuing benefits for industry, healthcare providers and, ultimately, patients.

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