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Catacchio I, Berardi S, Reale A, et al. Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation. Stem Cells Int. 2013;2013:589139doi: 10.1155/2013/589139.
Catacchio, I., Berardi, S., Reale, A., De Luisi, A., Racanelli, V., Vacca, A., & Ria, R. (2013). Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation. Stem cells international, 2013589139. https://doi.org/10.1155/2013/589139
Catacchio, Ivana, et al. "Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation." Stem cells international vol. 2013 (2013): 589139. doi: https://doi.org/10.1155/2013/589139
Catacchio I, Berardi S, Reale A, De Luisi A, Racanelli V, Vacca A, Ria R. Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation. Stem Cells Int. 2013;2013:589139. doi: 10.1155/2013/589139. Epub 2013 Mar 27. PMID: 23606860; PMCID: PMC3625599.
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Stem Cells Int. 2013;2013:589139. doi: 10.1155/2013/589139. Epub 2013 Mar 27.

Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation.

Stem cells international

Ivana Catacchio, Simona Berardi, Antonia Reale, Annunziata De Luisi, Vito Racanelli, Angelo Vacca, Roberto Ria

Affiliations

  1. Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I-70124 Bari, Italy.

PMID: 23606860 PMCID: PMC3625599 DOI: 10.1155/2013/589139

Abstract

In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted central dogmas of commitment of ASCs by showing their plasticity to differentiate across tissue lineage boundaries, irrespective of classical germ layer designations. The present paper supports the plasticity of the bone marrow stem cells (BMSCs), bringing the most striking and the latest evidences of the transdifferentiation properties of the bone marrow hematopoietic and mesenchymal stem cells (BMHSCs, and BMMSCs), the two BM populations of ASCs better characterized. In addition, we report the possible mechanisms that may explain these events, outlining the clinical importance of these phenomena and the relative problems.

References

  1. Hepatology. 2000 Jan;31(1):235-40 - PubMed
  2. J Mol Med (Berl). 2008 Dec;86(12):1301-14 - PubMed
  3. Stem Cells. 2011 Jun;29(6):888-94 - PubMed
  4. Hepatology. 2000 Jul;32(1):11-6 - PubMed
  5. J Clin Invest. 2001 Jun;107(11):1395-402 - PubMed
  6. J Neurosci. 2004 May 12;24(19):4585-95 - PubMed
  7. J Cell Mol Med. 2012 May;16(5):1114-24 - PubMed
  8. Cell Mol Life Sci. 2006 Jul;63(14):1649-57 - PubMed
  9. Catheter Cardiovasc Interv. 2005 Jul;65(3):321-9 - PubMed
  10. Wound Repair Regen. 2006 May-Jun;14(3):325-35 - PubMed
  11. Curr Stem Cell Res Ther. 2006 Sep;1(3):411-8 - PubMed
  12. J Neurosci Res. 2004 Jul 15;77(2):192-204 - PubMed
  13. Rejuvenation Res. 2009 Oct;12(5):359-66 - PubMed
  14. J Neurosci Res. 2002 Sep 15;69(6):880-93 - PubMed
  15. Science. 1999 May 14;284(5417):1168-70 - PubMed
  16. Immunity. 1994 Sep;1(6):517-27 - PubMed
  17. Front Immunol. 2012 Jul 10;3:192 - PubMed
  18. Stem Cells. 2005 Mar;23(3):392-402 - PubMed
  19. BMC Genomics. 2008 Apr 11;9:166 - PubMed
  20. Science. 2000 Dec 1;290(5497):1775-9 - PubMed
  21. Mol Cell Biol. 1990 Jun;10(6):2703-14 - PubMed
  22. J Neurol Sci. 2001 Aug 15;189(1-2):49-57 - PubMed
  23. J Cell Biol. 2001 Nov 26;155(5):733-8 - PubMed
  24. Science. 2005 Jul 8;309(5732):314-7 - PubMed
  25. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16891-6 - PubMed
  26. Cytotherapy. 2007;9(1):35-43 - PubMed
  27. Yonsei Med J. 2012 Nov 1;53(6):1059-67 - PubMed
  28. Cell. 1997 Nov 28;91(5):661-72 - PubMed
  29. Clin Cancer Res. 2008 Mar 15;14(6):1678-85 - PubMed
  30. J Cell Biochem. 2012 Feb;113(2):590-8 - PubMed
  31. Stem Cell Rev. 2008 Summer;4(2):101-12 - PubMed
  32. Cell Commun Signal. 2011 May 14;9:12 - PubMed
  33. Nature. 2000 Mar 9;404(6774):193-7 - PubMed
  34. Cell Biol Int. 2011 Dec;35(12):1261-6 - PubMed
  35. Prog Mol Biol Transl Sci. 2012;111:217-41 - PubMed
  36. J Invasive Cardiol. 2006 Nov;18(11):552-6 - PubMed
  37. Biol Blood Marrow Transplant. 2000;6(3):262-71 - PubMed
  38. Immunol Rev. 2002 Sep;187:9-21 - PubMed
  39. Hum Gene Ther. 2011 Jan;22(1):3-17 - PubMed
  40. Curr Opin Immunol. 2001 Apr;13(2):180-5 - PubMed
  41. Clin Pharmacol Ther. 2007 Sep;82(3):252-64 - PubMed
  42. Cell. 1988 Jun 17;53(6):857-67 - PubMed
  43. Science. 2004 Jan 2;303(5654):83-6 - PubMed
  44. Stem Cells Dev. 2008 Feb;17(1):19-22 - PubMed
  45. Cytotherapy. 2006;8(4):315-7 - PubMed
  46. Stem Cells. 2007 Nov;25(11):2896-902 - PubMed
  47. Vox Sang. 2010 Feb;98(2):93-107 - PubMed
  48. Blood. 2007 Aug 15;110(4):1362-9 - PubMed
  49. Pediatr Transplant. 2003;7 Suppl 3:86-8 - PubMed
  50. Nature. 2002 Apr 4;416(6880):542-5 - PubMed
  51. Am J Blood Res. 2011;1(1):76-89 - PubMed
  52. PLoS One. 2012;7(9):e45538 - PubMed
  53. Curr Opin Genet Dev. 2001 Oct;11(5):513-9 - PubMed
  54. Stem Cells. 2005 Mar;23(3):383-91 - PubMed
  55. Int J Mol Med. 2008 Sep;22(3):325-32 - PubMed
  56. Blood. 2002 May 1;99(9):3089-101 - PubMed
  57. Biol Blood Marrow Transplant. 2001;7(12):680-7 - PubMed
  58. J Neurol Sci. 2005 Jun 15;233(1-2):121-3 - PubMed
  59. Transfus Med Hemother. 2010 Apr;37(2):66-73 - PubMed
  60. Nat Protoc. 2010 Apr;5(4):617-27 - PubMed
  61. Annu Rev Cell Dev Biol. 2003;19:1-22 - PubMed
  62. Science. 1998 Mar 6;279(5356):1528-30 - PubMed
  63. J Mol Med (Berl). 2012 Jul;90(7):773-82 - PubMed
  64. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10711-6 - PubMed
  65. Nature. 2003 Oct 30;425(6961):968-73 - PubMed
  66. Biol Res. 2012;45(3):207-14 - PubMed
  67. N Engl J Med. 2002 Mar 7;346(10):738-46 - PubMed
  68. Spine (Phila Pa 1976). 2011 Jun;36(13):997-1005 - PubMed
  69. Stem Cells Dev. 2007 Feb;16(1):7-23 - PubMed
  70. Nature. 1982 Jun 24;297(5868):691-3 - PubMed
  71. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4080-5 - PubMed
  72. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15484-9 - PubMed
  73. J Cell Sci. 2005 Sep 1;118(Pt 17):3925-36 - PubMed
  74. Biochem Biophys Res Commun. 2006 Nov 10;350(1):138-46 - PubMed
  75. Int J Biochem Cell Biol. 2011 Jan;43(1):5-9 - PubMed
  76. Immunol Rev. 2002 Sep;187:22-39 - PubMed
  77. FASEB J. 2004 Jun;18(9):980-2 - PubMed
  78. Blood. 1998 Jan 15;91(2):450-7 - PubMed
  79. Biomed Mater Eng. 2012;22(1-3):105-11 - PubMed
  80. Neuron. 2001 Apr;30(1):19-35 - PubMed
  81. Am J Transplant. 2011 Nov;11(11):2297-301 - PubMed
  82. PLoS One. 2011 Apr 29;6(4):e19195 - PubMed
  83. Nat Med. 2000 Nov;6(11):1229-34 - PubMed
  84. J Exp Med. 2000 Dec 18;192(12):1707-18 - PubMed
  85. Blood. 2002 Jan 15;99(2):472-8 - PubMed
  86. Oncogene. 2008 Jan 24;27(5):663-74 - PubMed
  87. Stem Cells. 2011 Feb;29(2):169-78 - PubMed
  88. Nature. 1999 Sep 23;401(6751):390-4 - PubMed
  89. Cytotherapy. 2010 Jul;12(4):566-8 - PubMed

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