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Papakostas ID, Macheras GA. Thyroid hormones and peripheral nerve regeneration. J Thyroid Res. 2013;2013:648395doi: 10.1155/2013/648395.
Papakostas, I. D., & Macheras, G. A. (2013). Thyroid hormones and peripheral nerve regeneration. Journal of thyroid research, 2013648395. https://doi.org/10.1155/2013/648395
Papakostas, Ioannis D, and Macheras, George A. "Thyroid hormones and peripheral nerve regeneration." Journal of thyroid research vol. 2013 (2013): 648395. doi: https://doi.org/10.1155/2013/648395
Papakostas ID, Macheras GA. Thyroid hormones and peripheral nerve regeneration. J Thyroid Res. 2013;2013:648395. doi: 10.1155/2013/648395. Epub 2013 Apr 02. PMID: 23607046; PMCID: PMC3628215.
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J Thyroid Res. 2013;2013:648395. doi: 10.1155/2013/648395. Epub 2013 Apr 02.

Thyroid hormones and peripheral nerve regeneration.

Journal of thyroid research

Ioannis D Papakostas, George A Macheras

Affiliations

  1. Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, Goudi, 11527 Athens, Greece.

PMID: 23607046 PMCID: PMC3628215 DOI: 10.1155/2013/648395

Abstract

Peripheral nerve regeneration is a unique process in which cellular rather than tissue response is involved. Depending on the extent and proximity of the lesion and the age and type of the neuronal soma, the cell body may either initiate a reparative response or may die. Microsurgical intervention may alter the prognosis after a peripheral nerve injury but to a certain extent. By altering the biochemical microenvironment of the neuron, we can increase the proportion of neurons that survive the injury and initiate the reparative response. Thyroid hormone critically regulates tissue growth and differentiation and plays a crucial role during organ development. Furthermore, recent research has provided new insight into thyroid hormone cellular action. Thyroid hormone regulates stress response intracellular signaling and targets molecules important for cytoskeletal stability and cell integrity. Changes in thyroid hormone signaling occur in nerve and other tissues, with important physiological consequences. The interest in thyroid hormone in the context of nerve regeneration has recently been revived.

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