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Kocabicak E, Terzi M, Alptekin O, et al. Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor. Surg Neurol Int. 2013;4:31doi: 10.4103/2152-7806.109464.
Kocabicak, E., Terzi, M., Alptekin, O., & Temel, Y. (2013). Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor. Surgical neurology international, 431. https://doi.org/10.4103/2152-7806.109464
Kocabicak, Ersoy, et al. "Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor." Surgical neurology international vol. 4 (2013): 31. doi: https://doi.org/10.4103/2152-7806.109464
Kocabicak E, Terzi M, Alptekin O, Temel Y. Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor. Surg Neurol Int. 2013 Mar 22;4:31. doi: 10.4103/2152-7806.109464. Print 2013. PMID: 23607053; PMCID: PMC3622375.
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Surg Neurol Int. 2013 Mar 22;4:31. doi: 10.4103/2152-7806.109464. Print 2013.

Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor.

Surgical neurology international

Ersoy Kocabicak, Murat Terzi, Onur Alptekin, Yasin Temel

Affiliations

  1. Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey ; Department of Neurosurgery and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

PMID: 23607053 PMCID: PMC3622375 DOI: 10.4103/2152-7806.109464

Abstract

BACKGROUND: Tremor is an important cause of disability in patients with multiple sclerosis (MS). It is an ongoing debate as to which brain region should be targeted in MS patients with complex tremors.

CASE DESCRIPTION: Here, we describe our experience with targeting thalamic tremor cells in the ventro-intermediate/ventro-oralis posterior (Vim/Vop) region in a patient with MS related complex tremor. Intraoperative multiple-microelectrode recordings showed the existence of tremor cells. Test stimulation produced the best effect when performed at the regions where tremor cells were recorded. Postoperative examination revealed a substantial improvement of the tremor.

CONCLUSION: Our case observation reveals the existence of a neurophysiological target for deep brain stimulation (DBS) in MS related tremor.

Keywords: Deep brain stimulation; multiple sclerosis; nucleus ventro-oralis posterior; thalamus; tremor cell; ventro-intermediate nucleus

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