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Braga D, Maini L, Grepioni F. Mechanochemical preparation of co-crystals. Chem Soc Rev. 2013;42(18):7638-48doi: 10.1039/c3cs60014a.
Braga, D., Maini, L., & Grepioni, F. (2013). Mechanochemical preparation of co-crystals. Chemical Society reviews, 42(18), 7638-48. https://doi.org/10.1039/c3cs60014a
Braga, Dario, et al. "Mechanochemical preparation of co-crystals." Chemical Society reviews vol. 42,18 (2013): 7638-48. doi: https://doi.org/10.1039/c3cs60014a
Braga D, Maini L, Grepioni F. Mechanochemical preparation of co-crystals. Chem Soc Rev. 2013 Sep 21;42(18):7638-48. doi: 10.1039/c3cs60014a. Epub 2013 Apr 03. PMID: 23549606.
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Chem Soc Rev. 2013 Sep 21;42(18):7638-48. doi: 10.1039/c3cs60014a. Epub 2013 Apr 03.

Mechanochemical preparation of co-crystals.

Chemical Society reviews

Dario Braga, Lucia Maini, Fabrizia Grepioni

Affiliations

  1. Dipartimento di Chimica "G. Ciamician", Via Selmi 2, 40126 Bologna, Italy. [email protected].

PMID: 23549606 DOI: 10.1039/c3cs60014a

Abstract

The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.

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