Display options
Share it on

Indian J Virol. 2010 Jun;21(1):8-17. doi: 10.1007/s13337-010-0012-1. Epub 2010 Sep 03.

Reemergence of Chikungunya virus in Indian Subcontinent.

Indian journal of virology : an official organ of Indian Virological Society

C V M Naresh Kumar, D V R Sai Gopal

Affiliations

  1. Department of Virology, College of Sciences, Sri Venkateswara University, Tirupati, 517502 India.

PMID: 23637474 PMCID: PMC3550762 DOI: 10.1007/s13337-010-0012-1

Abstract

Chikungunya virus (CHIKV), a reemerging arboviral disease of public health concern is characterized by a triad of fever, rash and arthralgia. It was responsible for a number of epidemics in Asia and Africa. The severity of the current epidemic can be judged by the fact that an estimated 1.38 million people in India and one-third of the La Reunion population (by April 2006) were affected by CHIKV. Aedes aegypti and Aedes albopictus are the major mosquitoes transmitting CHIKV in Asia. Various neurological complications and CHIKV associated deaths were encountered during the current outbreak (2005-2010). The aggressive nature of the recent CHIKV epidemic was attributed to the mutations in the viral genome in addition to their adaptation and spread to vectors like Aedes albopictus. Proper diet, adequate rest and symptomatic treatment using non-salicylate analgesics and Non-steroidal anti inflammatory drugs (NSAIDS) helped the patients in recovering from CHIKV infections. In the absence of an effective vaccine, rapid implementation of mosquito control measures and establishment of a system for continuous surveillance of the disease seems to be the only possible solution to prevent any such outbreak in the near future.

Keywords: Aedes mosquito; CHIKV; Co-infection; Differential diagnosis; Mutation; RT-PCR; Vaccine

References

  1. Microbes Infect. 2009 Dec;11(14-15):1197-205 - PubMed
  2. PLoS One. 2008 Aug 26;3(8):e3066 - PubMed
  3. In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):491-5 - PubMed
  4. J Clin Virol. 2009 Jun;45(2):163-4 - PubMed
  5. Indian J Med Res. 2007 Dec;126(6):534-40 - PubMed
  6. J Gen Virol. 2007 Sep;88(Pt 9):2363-2377 - PubMed
  7. J Infect Dis. 2009 Aug 15;200(4):516-23 - PubMed
  8. Trans R Soc Trop Med Hyg. 2005 Feb;99(2):128-41 - PubMed
  9. J Med Virol. 2002 Jul;67(3):370-4 - PubMed
  10. Emerg Infect Dis. 2007 Aug;13(8):1259-60 - PubMed
  11. Biochem Biophys Res Commun. 2008 Nov 28;376(4):718-22 - PubMed
  12. Transfusion. 2008 Jul;48(7):1333-41 - PubMed
  13. S Afr Med J. 1984 Aug 11;66(6):217-8 - PubMed
  14. Lancet. 2006 Jul 15;368(9531):258 - PubMed
  15. Indian J Med Res. 1965 Aug;53(8):715-9 - PubMed
  16. Indian J Med Res. 1964 Jul;52:676-83 - PubMed
  17. Virus Res. 2008 Jul;135(1):36-41 - PubMed
  18. Am J Trop Med Hyg. 1999 Feb;60(2):281-6 - PubMed
  19. J Mol Biol. 1983 Jul 25;168(1):1-15 - PubMed
  20. Indian J Med Res. 1964 Jul;52:651-9 - PubMed
  21. J Biosci. 2008 Nov;33(4):443-9 - PubMed
  22. J Clin Virol. 2007 Aug;39(4):271-5 - PubMed
  23. Microbiol Rev. 1994 Sep;58(3):491-562 - PubMed
  24. Indian J Med Res. 2009 Apr;129(4):438-41 - PubMed
  25. PLoS One. 2007 Nov 14;2(11):e1168 - PubMed
  26. Am J Trop Med Hyg. 2008 Mar;78(3):422-5 - PubMed
  27. Am J Trop Med Hyg. 2000 Jun;62(6):681-5 - PubMed
  28. PLoS Negl Trop Dis. 2009;3(3):e389 - PubMed
  29. PLoS Pathog. 2008 Feb 8;4(2):e29 - PubMed
  30. PLoS Med. 2006 Jul;3(7):e263 - PubMed
  31. Indian J Med Res. 1964 Jul;52:698-702 - PubMed
  32. J Vet Med B Infect Dis Vet Public Health. 2002 Feb;49(1):49-54 - PubMed
  33. Epidemiol Infect. 2009 Apr;137(4):534-41 - PubMed
  34. Lancet Infect Dis. 2007 May;7(5):319-27 - PubMed
  35. Jpn J Infect Dis. 2009 Jul;62(4):303-5 - PubMed
  36. PLoS Pathog. 2007 Dec;3(12):e201 - PubMed
  37. Presse Med. 2006 May;35(5 Pt 1):785-8 - PubMed
  38. J Clin Virol. 2007 Jul;39(3):188-93 - PubMed
  39. Antiviral Res. 2004 Feb;61(2):111-7 - PubMed
  40. J Gen Virol. 2000 Feb;81(Pt 2):471-9 - PubMed
  41. Lancet Infect Dis. 2008 Jan;8(1):3-4 - PubMed
  42. Epidemiol Infect. 2008 Feb;136(2):196-206 - PubMed
  43. J Clin Invest. 2010 Mar;120(3):894-906 - PubMed
  44. J Gen Virol. 2007 Jul;88(Pt 7):1967-1976 - PubMed
  45. J Vector Borne Dis. 2006 Dec;43(4):151-60 - PubMed
  46. Int J Clin Pract. 2007 Nov;61(11):1941 - PubMed
  47. Emerg Infect Dis. 2008 Mar;14(3):412-5 - PubMed
  48. Trends Microbiol. 2008 Feb;16(2):80-8 - PubMed
  49. Emerg Infect Dis. 2009 Jul;15(7):1077-80 - PubMed
  50. J Virol Methods. 2005 Mar;124(1-2):65-71 - PubMed
  51. PLoS One. 2009;4(1):e4261 - PubMed
  52. J Virol Methods. 2008 Apr;149(1):175-9 - PubMed
  53. Indian J Med Res. 2009 Apr;129(4):442-5 - PubMed
  54. Indian J Med Res. 2002 Apr;115:144-8 - PubMed
  55. Travel Med Infect Dis. 2008 May;6(3):152-4 - PubMed
  56. Trans R Soc Trop Med Hyg. 1992 Jul-Aug;86(4):438-42 - PubMed
  57. Lancet Infect Dis. 2007 May;7(5):306-7 - PubMed
  58. J Travel Med. 2007 Sep-Oct;14(5):320-5 - PubMed
  59. Mol Cell Biol. 1993 Sep;13(9):5331-47 - PubMed
  60. J Vector Borne Dis. 2009 Mar;46(1):26-35 - PubMed
  61. Emerg Infect Dis. 2006 Oct;12(10):1580-3 - PubMed
  62. J Med Virol. 2004 Oct;74(2):277-82 - PubMed
  63. Emerg Infect Dis. 2009 Apr;15(4):591-3 - PubMed
  64. Nat Med. 2010 Mar;16(3):334-8 - PubMed
  65. S Afr Med J. 1983 Feb 26;63(9):313-5 - PubMed
  66. J Rheumatol. 1980 Mar-Apr;7(2):231-6 - PubMed
  67. Am J Trop Med Hyg. 1969 Nov;18(6):954-71 - PubMed
  68. Neurol India. 2009 Mar-Apr;57(2):113-5 - PubMed
  69. Indian J Med Res. 1964 Jul;52:684-91 - PubMed
  70. Natl Med J India. 2006 Nov-Dec;19(6):315-22 - PubMed
  71. Microbes Infect. 2009 Dec;11(14-15):1165-76 - PubMed
  72. J Biosci. 2008 Nov;33(4):617-28 - PubMed
  73. J Gen Virol. 2008 Aug;89(Pt 8):1945-1948 - PubMed

Publication Types