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Keshavarzi Z, Khaksari M, Razmi Z, et al. The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats. Iran J Basic Med Sci. 2012;15(5):1102-5
Keshavarzi, Z., Khaksari, M., Razmi, Z., Soltani Hekmat, A., Naderi, V., & Rostami, S. (2012). The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats. Iranian journal of basic medical sciences, 15(5), 1102-5.
Keshavarzi, Zakieh, et al. "The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats." Iranian journal of basic medical sciences vol. 15,5 (2012): 1102-5.
Keshavarzi Z, Khaksari M, Razmi Z, Soltani Hekmat A, Naderi V, Rostami S. The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats. Iran J Basic Med Sci. 2012 Sep;15(5):1102-5. PMID: 23492757; PMCID: PMC3586930.
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Iran J Basic Med Sci. 2012 Sep;15(5):1102-5.

The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats.

Iranian journal of basic medical sciences

Zakieh Keshavarzi, Mohammad Khaksari, Zohre Razmi, Ava Soltani Hekmat, Vida Naderi, Sima Rostami

Affiliations

  1. North Khorasan University of Medical Sciences, Bojnord, Iran.

PMID: 23492757 PMCID: PMC3586930

Abstract

OBJECTIVES: Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats.

MATERIALS AND METHODS: Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations were quantified by ELISA kits.

RESULTS: Groups showed no significant difference in brain IL-10 either after TBI induction or after treatment with ibuprofen or celecoxib. Serum IL-10 in vehicle or ibuprofen treated animals was lower than in sham groups (P< 0.01). Brain IL-1β decreased after treatment by ibuprofen or celecoxib (P< 0.001). There was no statistical difference in serum IL-1β in TBI and intact. Serum IL-1β significantly decreased in rats that received celecoxib compared to TBI group (P< 0.01).

CONCLUSION: Based on our study IL-1β can decrease through both cyclooxygenase 1 (COX-1) and COX-2 pathway but serum IL-1β can decrease only by COX-2 pathway.

Keywords: Brain injury; Celecoxib; Ibuprofen; Interleukin-10

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