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Castrillo A, Cardoso M, Rouse L. Treatment of buffy coat platelets in platelet additive solution with the mirasol(®) pathogen reduction technology system. Transfus Med Hemother. 2013;40(1):44-8doi: 10.1159/000345679.
Castrillo, A., Cardoso, M., & Rouse, L. (2013). Treatment of buffy coat platelets in platelet additive solution with the mirasol(®) pathogen reduction technology system. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(1), 44-8. https://doi.org/10.1159/000345679
Castrillo, Azucena, et al. "Treatment of buffy coat platelets in platelet additive solution with the mirasol(®) pathogen reduction technology system." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 40,1 (2013): 44-8. doi: https://doi.org/10.1159/000345679
Castrillo A, Cardoso M, Rouse L. Treatment of buffy coat platelets in platelet additive solution with the mirasol(®) pathogen reduction technology system. Transfus Med Hemother. 2013 Feb;40(1):44-8. doi: 10.1159/000345679. Epub 2013 Jan 03. PMID: 23637649; PMCID: PMC3635978.
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Transfus Med Hemother. 2013 Feb;40(1):44-8. doi: 10.1159/000345679. Epub 2013 Jan 03.

Treatment of buffy coat platelets in platelet additive solution with the mirasol(®) pathogen reduction technology system.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Azucena Castrillo, Marcia Cardoso, Lindsay Rouse

Affiliations

  1. Centro de Transfusion de Galicia, Santiago de Compostela, Spain.

PMID: 23637649 PMCID: PMC3635978 DOI: 10.1159/000345679

Abstract

BACKGROUND: The Mirasol pathogen reduction technology (PRT) system uses riboflavin and ultraviolet light and is currently approved and used in Europe for the treatment of platelets and plasma. Mirasol treatment is intended to reduce the infectious pathogen load and to inactivate leukocytes in blood products. Our objective was to evaluate buffy coat platelet concentrates (BCPCs) prepared with platelet additive solution (PAS) and treated with the Mirasol system and to examine the effects on platelet cell quality during storage.

METHODS: 26 BCPCs were prepared and split, creating 13 paired control and test units. The test units were treated with the Mirasol system and the platelet quality was assessed in all units over 7 days of storage.

RESULTS: All products met the incoming specifications for Mirasol treatment, and the pH of all Mirasol-treated BCPCs in PAS met the requirements of the Council of Europe guidelines throughout storage. Analysis of lactate production and glucose consumption rates, CD62p expression and cytokines indicates enhanced cellular metabolism in treated platelets, but the levels were within previously published ranges.

CONCLUSION: While Mirasol-treated BCPCs in PAS had increased metabolism and activation compared to controls, the results indicate that these units can be stored for 7 days with acceptable cell quality.

Keywords: Buffy coat platelets; Mirasol; PAS-IIIM; Pathogen reduction technology

References

  1. Transfus Med Hemother. 2011;38(1):8-18 - PubMed
  2. Transfus Med Rev. 2008 Jan;22(1):1-34 - PubMed
  3. Transfusion. 2010 Nov;50(11):2362-75 - PubMed
  4. Blood Transfus. 2010 Jul;8(3):186-92 - PubMed
  5. Nat Med. 2004 Dec;10(12 Suppl):S98-109 - PubMed
  6. Vox Sang. 2009 Jul;97(1):26-33 - PubMed
  7. Transfusion. 2010 Nov;50(11):2461-73 - PubMed
  8. Transfusion. 2011 Feb;51(2):344-56 - PubMed
  9. Transfus Apher Sci. 2008 Aug;39(1):75-82 - PubMed
  10. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11877-82 - PubMed
  11. Transfusion. 2008 Jul;48(7):1333-41 - PubMed
  12. Transfusion. 1999 Nov-Dec;39(11-12):1179-84 - PubMed
  13. Transfusion. 2011 Jul;51(7):1397-404 - PubMed
  14. Vox Sang. 2010 Aug 1;99(2):193-4 - PubMed
  15. Vox Sang. 2006 May;90(4):279-85 - PubMed
  16. Transplantation. 2007 Nov 15;84(9):1174-82 - PubMed
  17. Transfusion. 2011 Jul;51(7):1369-76 - PubMed
  18. Transfusion. 2010 Oct;50(10):2210-9 - PubMed
  19. Transfusion. 2005 Aug;45(8):1335-41 - PubMed
  20. Transfusion. 2010 Nov;50(11):2489-98 - PubMed

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