Display options
Cite
Wichianpitaya J, Taneepanichskul S. A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstet Gynecol Int. 2013;2013:487143doi: 10.1155/2013/487143.
Wichianpitaya, J., & Taneepanichskul, S. (2013). A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstetrics and gynecology international, 2013487143. https://doi.org/10.1155/2013/487143
Wichianpitaya, Jirath, and Taneepanichskul, Surasak. "A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms." Obstetrics and gynecology international vol. 2013 (2013): 487143. doi: https://doi.org/10.1155/2013/487143
Wichianpitaya J, Taneepanichskul S. A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstet Gynecol Int. 2013;2013:487143. doi: 10.1155/2013/487143. Epub 2013 Feb 20. PMID: 23577032; PMCID: PMC3609439.
Copy Download .nbib Format: NLM
Share it on

Obstet Gynecol Int. 2013;2013:487143. doi: 10.1155/2013/487143. Epub 2013 Feb 20.

A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms.

Obstetrics and gynecology international

Jirath Wichianpitaya, Surasak Taneepanichskul

Affiliations

  1. Family Planning Unit, Reproductive Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Bangkok 10330, Thailand.

PMID: 23577032 PMCID: PMC3609439 DOI: 10.1155/2013/487143

Abstract

Objective. To compare the efficacy of low-dose COC containing desogestrel (DSG) with drospirenone (DRSP) in the changes of premenstrual symptoms. Methods. In an open-label randomized controlled trial, 90 women with premenstrual syndrome who required COC were randomly recruited and allocated equally to receive either 6 cycles of 20 micrograms ethinyl estradiol (EE)/150 micrograms DSG (DSG group) or 20 micrograms EE/3 mg DRSP (DRSP group) in 24/4 extended regimen. Analysis of covariance and repeated analysis of variance were used to determine the difference of mean Women's Health Assessment Questionnaire (WHAQ) scores changes between groups, within group, and in premenstrual, menstrual, and postmenstrual phases. Results. Baseline characteristics and WHAQ scores were comparable. At the ends of the 3rd and the 6th cycles, mean WHAQ scores of all the 3 phases in DRSP group showed significant reduction and were significantly lower than those in DSG group. DSG group showed significant reduction in both premenstrual and menstrual phases after the 6th cycle. Adverse effects were comparable in both groups. In conclusion, low-dose COC containing either DSG or DRSP reduced premenstrual symptoms, but the latter showed greater efficacy and earlier reduction.

References

  1. J Reprod Med. 2003 Feb;48(2):79-85 - PubMed
  2. Fertil Steril. 2004 Mar;81(3):645-51 - PubMed
  3. Physiol Behav. 1997 Aug;62(2):431-5 - PubMed
  4. Contraception. 2004 Sep;70(3):191-8 - PubMed
  5. Contraception. 1996 Aug;54(2):71-7 - PubMed
  6. Contraception. 2005 Dec;72(6):414-21 - PubMed
  7. Contraception. 2004 Oct;70(4):281-7 - PubMed
  8. Expert Opin Pharmacother. 2007 May;8(7):989-99 - PubMed
  9. J Reprod Med. 2006 Apr;51(4 Suppl):339-47 - PubMed
  10. Contraception. 2004 Jun;69(6):469-76 - PubMed
  11. Am J Obstet Gynecol. 1969 Feb 1;103(3):390-402 - PubMed
  12. J Reprod Med. 2006 Apr;51(4 Suppl):359-70 - PubMed
  13. Contraception. 2000 Jul;62(1):29-38 - PubMed
  14. Contraception. 2005 Jan;71(1):1-7 - PubMed
  15. Arch Womens Ment Health. 2006 Jan;9(1):1-14 - PubMed
  16. Fertil Steril. 1999 Jul;72(1):115-20 - PubMed
  17. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD006586 - PubMed
  18. Obstet Gynecol. 2005 Sep;106(3):492-501 - PubMed
  19. Contraception. 2006 Aug;74(2):100-3 - PubMed
  20. Acta Obstet Gynecol Scand. 2000 May;79(5):405-13 - PubMed
  21. Climacteric. 2003 Oct;6 Suppl 3:49-54 - PubMed
  22. Arch Womens Ment Health. 2011 Feb;14(1):13-21 - PubMed
  23. Obstet Gynecol. 2000 Feb;95(2):261-6 - PubMed
  24. J Reprod Med. 1985 Feb;30(2):113-26 - PubMed
  25. Arch Gynecol Obstet. 2007 Jun;275(6):433-8 - PubMed

Publication Types