Display options
Cite
O'Malley MW, Fishman RL, Ciraulo DA, et al. Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats. Front Neurol. 2013;4:15doi: 10.3389/fneur.2013.00015.
O'Malley, M. W., Fishman, R. L., Ciraulo, D. A., & Datta, S. (2013). Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats. Frontiers in neurology, 415. https://doi.org/10.3389/fneur.2013.00015
O'Malley, Matthew W, et al. "Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats." Frontiers in neurology vol. 4 (2013): 15. doi: https://doi.org/10.3389/fneur.2013.00015
O'Malley MW, Fishman RL, Ciraulo DA, Datta S. Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats. Front Neurol. 2013 Feb 26;4:15. doi: 10.3389/fneur.2013.00015. eCollection 2013. PMID: 23550195; PMCID: PMC3581761.
Copy Download .nbib Format: NLM
Share it on

Front Neurol. 2013 Feb 26;4:15. doi: 10.3389/fneur.2013.00015. eCollection 2013.

Effect of five-consecutive-day exposure to an anxiogenic stressor on sleep-wake activity in rats.

Frontiers in neurology

Matthew W O'Malley, Rachel Lea Fishman, Domenic A Ciraulo, Subimal Datta

Affiliations

  1. Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry, Boston University School of Medicine Boston, MA, USA.

PMID: 23550195 PMCID: PMC3581761 DOI: 10.3389/fneur.2013.00015

Abstract

Repeated exposure to an anxiogenic stressor (AS) is a known environmental factor for the development of depression, yet the progression of sleep-wake (S-W) changes associated with the onset of AS-induced depression (ASID) is not completely understood. Thus, the aim of this study was to identify these progressive S-W changes by developing ASID in rats, via repeated exposure to an AS, and compare this ASID-associated sleep phenotype with the sleep phenotype of human depression. To achieve this aim, rats were first recorded for a 6 h period of baseline S-W activity without AS. Then, rats were subjected to 5 days of AS [Day 1: inescapable foot-shock; 5 trials of 3 s foot-shocks (1.0 mA) at 3 min intervals; Days 3-5: 15 trials of 5 s foot-shocks at 45 s intervals]. S-W activity was recorded for 6 h immediately after each AS treatment session. Two days later rats were again recorded for 6 h of S-W activity, but with no exposure to the AS (NASD). Compared to the baseline day: Day 1 of AS (ASD-1) increased wakefulness, slow-wave sleep (SWS) latency, and rapid-eye movement (REM) sleep latency, but decreased the total amount of REM sleep; ASD-2 animals remained awake throughout the 6 h S-W recording period; ASD-3, ASD-4, and ASD-5 (ASDs-3-5) decreased wakefulness, SWS latency, and REM sleep latency, but increased the total amount of REM sleep. Interestingly, these results reveal that initial exposure to the AS versus later, repeated exposure to the AS produced opposing S-W changes. On NASD, animals exhibited baseline-like S-W activity, except slightly less REM sleep. These results suggest that repeated AS produces a sleep phenotype that resembles the sleep phenotype of depression in humans, but consistent re-exposure to the AS is required. These results are promising because the methodological simplicity and reversibility of the ASID-associated S-W phenotype could be more advantageous than other animal models for studying the pathophysiological mechanisms that underlie the expression of ASID.

Keywords: anxiety; depression; foot-shock; rat model; sleep-wake

References

  1. Neuroscience. 2008 Jun 2;153(4):875-80 - PubMed
  2. Behav Brain Res. 2010 Jun 26;210(1):54-66 - PubMed
  3. Eur J Pharmacol. 2002 Nov 22;455(1):35-41 - PubMed
  4. J Clin Psychiatry. 2006 Nov;67(11):1665-73 - PubMed
  5. Acta Psychiatr Scand. 2012 Jun;125(6):468-77 - PubMed
  6. N Engl J Med. 2001 Dec 20;345(25):1825-32 - PubMed
  7. Arch Intern Med. 1993 Nov 8;153(21):2474-80 - PubMed
  8. J Neurosci Res. 2002 Nov 15;70(4):611-21 - PubMed
  9. Psychol Bull. 2009 Sep;135(5):731-48 - PubMed
  10. J Clin Psychiatry. 1983 Aug;44(8 Pt 2):8-11 - PubMed
  11. Behav Neurosci. 1994 Apr;108(2):265-76 - PubMed
  12. Biol Psychiatry. 1985 Jul;20(7):764-84 - PubMed
  13. Sleep. 2010 May;33(5):621-30 - PubMed
  14. Prev Med. 2011 Oct;53(4-5):284-8 - PubMed
  15. Neurosci Biobehav Rev. 2008;32(1):99-117 - PubMed
  16. J ECT. 2012 Jun;28(2):92-7 - PubMed
  17. Pharmacol Ther. 1990;45(3):425-55 - PubMed
  18. Arch Gen Psychiatry. 1979 Jan;36(1):85-90 - PubMed
  19. Biol Psychiatry. 1976 Apr;11(2):159-74 - PubMed
  20. Q J Exp Psychol A. 2000 Feb;53(1):271-9 - PubMed
  21. Sleep Med Rev. 2000 Jun;4(3):263-276 - PubMed
  22. Sleep. 1987 Jun;10(3):199-215 - PubMed
  23. Physiol Behav. 2008 Nov 28;95(4):553-61 - PubMed
  24. Brain Res Cogn Brain Res. 2002 Nov;14(3):317-24 - PubMed
  25. J Neurosci. 2004 Feb 11;24(6):1416-27 - PubMed
  26. Brain Res. 2007 Aug 20;1164:72-80 - PubMed
  27. Physiol Behav. 2011 Feb 1;102(2):170-4 - PubMed
  28. Sleep. 2008 May;31(5):673-90 - PubMed
  29. Biol Psychiatry. 2005 Sep 1;58(5):347-54 - PubMed
  30. Behav Neurosci. 1994 Apr;108(2):254-64 - PubMed
  31. Sleep Med Rev. 2004 Apr;8(2):119-32 - PubMed
  32. Nat Neurosci. 2000 Dec;3(12):1237-8 - PubMed
  33. J Psychiatr Res. 2003 Jan-Feb;37(1):9-15 - PubMed
  34. Behav Brain Res. 2011 Sep 23;222(2):351-6 - PubMed
  35. Physiol Behav. 1991 Feb;49(2):257-62 - PubMed
  36. Learn Mem. 2001 Mar-Apr;8(2):112-9 - PubMed
  37. Neuroreport. 2000 Feb 28;11(3):627-31 - PubMed
  38. Biol Psychiatry. 1995 Jan 15;37(2):85-98 - PubMed
  39. Acta Psychiatr Scand. 1998 Sep;98(3):187-92 - PubMed
  40. Eur J Neurosci. 2008 Apr;27(7):1876-92 - PubMed
  41. Pharmakopsychiatr Neuropsychopharmakol. 1978 Jan;11(1):17-26 - PubMed
  42. J Gen Intern Med. 1992 Mar-Apr;7(2):170-3 - PubMed
  43. Science. 1994 Jul 29;265(5172):679-82 - PubMed
  44. J Aging Health. 2009 Sep;21(6):864-80 - PubMed
  45. Arch Gen Psychiatry. 1976 Sep;33(9):1124-7 - PubMed
  46. Neurophysiol Clin. 2006 May-Jun;36(3):157-83 - PubMed
  47. Br J Psychiatry. 1992 Apr;160:519-24 - PubMed
  48. J Clin Psychopharmacol. 1997 Apr;17 Suppl 1:2S-18S - PubMed
  49. J Neurosci. 2000 Nov 15;20(22):8607-13 - PubMed
  50. Sleep. 2011 Jun 01;34(6):759-71 - PubMed
  51. Indian J Pharmacol. 2012 Mar;44(2):173-7 - PubMed
  52. J Clin Psychiatry. 1997 Nov;58(11):501-8 - PubMed
  53. Nature. 2004 Jul 1;430(6995):78-81 - PubMed
  54. PLoS One. 2012;7(3):e33745 - PubMed
  55. Behav Brain Res. 1995 Jul-Aug;69(1-2):137-45 - PubMed

Publication Types

Grant support