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Keenan AV, Spivakovksy S. Stress associated with onset of recurrent aphthous stomatitis. Evid Based Dent. 2013;14(1):25doi: 10.1038/sj.ebd.6400919.
Keenan, A. V., & Spivakovksy, S. (2013). Stress associated with onset of recurrent aphthous stomatitis. Evidence-based dentistry, 14(1), 25. https://doi.org/10.1038/sj.ebd.6400919
Keenan, Analia Veitz, and Spivakovksy, Silvia. "Stress associated with onset of recurrent aphthous stomatitis." Evidence-based dentistry vol. 14,1 (2013): 25. doi: https://doi.org/10.1038/sj.ebd.6400919
Keenan AV, Spivakovksy S. Stress associated with onset of recurrent aphthous stomatitis. Evid Based Dent. 2013 Mar;14(1):25. doi: 10.1038/sj.ebd.6400919. PMID: 23579306.
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Evid Based Dent. 2013 Mar;14(1):25. doi: 10.1038/sj.ebd.6400919.

Stress associated with onset of recurrent aphthous stomatitis.

Evidence-based dentistry

Analia Veitz Keenan, Silvia Spivakovksy

Affiliations

  1. NYU College of Dentistry, New York, USA.

PMID: 23579306 DOI: 10.1038/sj.ebd.6400919

Abstract

DESIGN: Randomised controlled trial (RCT).

INTERVENTION: One hundred and sixty patients participating in a RCT in which they were randomised to multivitamins (n=81) or placebo (n=79) completed ulcer diaries and a weekly telephone survey by calling an automated interactive voice response (IVR) system. Stressful events were quantified using the validated Recent Life Changes Questionnaire (RLCQ) and were classified as mental or physical stressors.

OUTCOME MEASURE: Onset and duration of RAS episodes

RESULTS: Stressful life events were significantly associated with the onset of RAS episodes (P < 0.001), but not with the duration of the RAS episodes. Experiencing a stressful life event increased the odds of an RAS episode by almost three times (OR = 2.72; 95% CI = 2.04-3.62). When controlled for each other, mental stressors had a larger effect (OR = 3.46, 95% CI = 2.54- 4.72) than physical stressors (OR = 1.44; 95% CI = 1.04- 1.99) on the occurrence of RAS episodes. RAS episodes did not occur more frequently or last longer with increasing stress severity.

CONCLUSIONS: In patients with a history of RAS, stressful events may mediate changes involved in the initiation of new RAS episodes. Mental stressors are more strongly associated with RAS episodes than physical stressors.

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