Display options
Cite
Koneri K, Hirono Y, Fujimoto D, et al. Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report. J Gastric Cancer. 2013;13(1):58-64doi: 10.5230/jgc.2013.13.1.58.
Koneri, K., Hirono, Y., Fujimoto, D., Sawai, K., Morikawa, M., Murakami, M., Goi, T., Iida, A., Katayama, K., & Yamaguchi, A. (2013). Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report. Journal of gastric cancer, 13(1), 58-64. https://doi.org/10.5230/jgc.2013.13.1.58
Koneri, Kenji, et al. "Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report." Journal of gastric cancer vol. 13,1 (2013): 58-64. doi: https://doi.org/10.5230/jgc.2013.13.1.58
Koneri K, Hirono Y, Fujimoto D, Sawai K, Morikawa M, Murakami M, Goi T, Iida A, Katayama K, Yamaguchi A. Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report. J Gastric Cancer. 2013 Mar;13(1):58-64. doi: 10.5230/jgc.2013.13.1.58. Epub 2013 Mar 31. PMID: 23610720; PMCID: PMC3627808.
Copy Download .nbib Format: NLM
Share it on

J Gastric Cancer. 2013 Mar;13(1):58-64. doi: 10.5230/jgc.2013.13.1.58. Epub 2013 Mar 31.

Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report.

Journal of gastric cancer

Kenji Koneri, Yasuo Hirono, Daisuke Fujimoto, Katsuji Sawai, Mitsuhiro Morikawa, Makoto Murakami, Takanori Goi, Atsushi Iida, Kanji Katayama, Akio Yamaguchi

Affiliations

  1. Department of Gastroenterological Surgery, University of Fukui, Fukui, Japan.

PMID: 23610720 PMCID: PMC3627808 DOI: 10.5230/jgc.2013.13.1.58

Abstract

Alpha-fetoprotein-Producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a Borrmann II-like tumor in the lower part of the stomach. Computed tomography revealed a tumor in the left lobe of the liver. Serum alpha-fetoprotein levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/gimeracil/oteracil potassium and administered hepatic intra-arterial cisplatin injection. Liver metastasis showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After sorafenib tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of sorafenib tosylate may potentially improve the prognosis in such cases.

Keywords: Alpha-fetoproteins; Drug therapy; General surgery; Sorafenib; Stomach neoplasms

References

  1. N Engl J Med. 2008 Jul 24;359(4):378-90 - PubMed
  2. Dig Surg. 2002;19(5):359-65; discussion 365 - PubMed
  3. Gan To Kagaku Ryoho. 2009 Nov;36(12):2326-9 - PubMed
  4. Invest New Drugs. 2012 Feb;30(1):306-15 - PubMed
  5. Oncology. 2004;66(6):445-9 - PubMed
  6. Gan To Kagaku Ryoho. 2000 Oct;27(12):1920-3 - PubMed
  7. Gan To Kagaku Ryoho. 2011 Jan;38(1):105-8 - PubMed
  8. Hepatogastroenterology. 2006 May-Jun;53(69):338-41 - PubMed
  9. J Gastric Cancer. 2011 Mar;11(1):23-30 - PubMed
  10. Oncology. 2000 Aug;59(2):145-51 - PubMed
  11. Gan To Kagaku Ryoho. 2002 Nov;29(11):1985-8 - PubMed
  12. Oncology. 2003;65(2):95-101 - PubMed
  13. Drug Discov Ther. 2011 Feb;5(1):2-11 - PubMed
  14. Br J Surg. 2010 Jul;97(7):1056-61 - PubMed

Publication Types