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Sah C, Aridogan IA, Izol V, et al. Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs. Korean J Urol. 2013;54(3):199-203doi: 10.4111/kju.2013.54.3.199.
Sah, C., Aridogan, I. A., Izol, V., Erdogan, S., & Doran, S. (2013). Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs. Korean journal of urology, 54(3), 199-203. https://doi.org/10.4111/kju.2013.54.3.199
Sah, Cem, et al. "Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs." Korean journal of urology vol. 54,3 (2013): 199-203. doi: https://doi.org/10.4111/kju.2013.54.3.199
Sah C, Aridogan IA, Izol V, Erdogan S, Doran S. Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs. Korean J Urol. 2013 Mar;54(3):199-203. doi: 10.4111/kju.2013.54.3.199. Epub 2013 Mar 15. PMID: 23524493; PMCID: PMC3604575.
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Korean J Urol. 2013 Mar;54(3):199-203. doi: 10.4111/kju.2013.54.3.199. Epub 2013 Mar 15.

Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs.

Korean journal of urology

Cem Sah, Ibrahim Atilla Aridogan, Volkan Izol, Seyda Erdogan, Saban Doran

Affiliations

  1. Department of Urology, University of Cukurova Faculty of Medicine, Adana, Turkey.

PMID: 23524493 PMCID: PMC3604575 DOI: 10.4111/kju.2013.54.3.199

Abstract

PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels.

MATERIALS AND METHODS: Thirty male rats aged 4 to 5 months were studied. A DHEAS suspension of 5 mg/kg per rat was administered orally to the 15 rats in the experimental group 5 times a week, whereas saline was administered concurrently to the 15 rats in the control group. Intracardiac blood samples were drawn to determine hormone levels, and histological samples of prostate and testes were evaluated under light microscopy.

RESULTS: At the end of the 6-month study period, histological examinations performed on prostate preparations showed that the atrophy score of the experimental group was significantly lower than the scores of the sham and control groups (p<0.001 and p<0.001, respectively). The serum total testosterone and DHEAS levels of the rats in the study group were significantly increased (p<0.001).

CONCLUSIONS: In our study, we determined that the long-term use of DHEAS does not have any detrimental effects on the prostate or the testis; on the contrary, it protects the prostate from atrophy, which is imperative for the continuation of fertility as well as for increasing serum testosterone and DHEAS levels.

Keywords: Aging; Dehydroepiandrosterone sulfate; Prostate; Testis

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