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Di Battista AP, Rhind SG, Baker AJ. Application of blood-based biomarkers in human mild traumatic brain injury. Front Neurol. 2013;4:44doi: 10.3389/fneur.2013.00044.
Di Battista, A. P., Rhind, S. G., & Baker, A. J. (2013). Application of blood-based biomarkers in human mild traumatic brain injury. Frontiers in neurology, 444. https://doi.org/10.3389/fneur.2013.00044
Di Battista, Alex P, et al. "Application of blood-based biomarkers in human mild traumatic brain injury." Frontiers in neurology vol. 4 (2013): 44. doi: https://doi.org/10.3389/fneur.2013.00044
Di Battista AP, Rhind SG, Baker AJ. Application of blood-based biomarkers in human mild traumatic brain injury. Front Neurol. 2013 May 01;4:44. doi: 10.3389/fneur.2013.00044. eCollection 2013. PMID: 23641234; PMCID: PMC3640204.
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Front Neurol. 2013 May 01;4:44. doi: 10.3389/fneur.2013.00044. eCollection 2013.

Application of blood-based biomarkers in human mild traumatic brain injury.

Frontiers in neurology

Alex P Di Battista, Shawn G Rhind, Andrew J Baker

Affiliations

  1. Faculty of Medicine, Institute of Medical Science, University of Toronto Toronto, ON, Canada.

PMID: 23641234 PMCID: PMC3640204 DOI: 10.3389/fneur.2013.00044

Abstract

Traumatic Brain Injury (TBI) is a global health concern. The majority of TBI's are mild, yet our ability to diagnose and treat mild traumatic brain injury (mTBI) is lacking. This deficiency results from a variety of issues including the difficulty in interpreting ambiguous clinically presented symptoms, and ineffective imaging techniques. Thus, researchers have begun to explore cellular and molecular based approaches to improve both diagnosis and prognosis. This has been met with a variety of challenges, including difficulty in relating biological markers to current clinical symptoms, and overcoming our lack of fundamental understanding of the pathophysiology of mTBI. However, recent adoption of high throughput technologies and a change in focus from the identification of single to multiple markers has given just optimism to mTBI research. The purpose of this review is to highlight a number of current experimental peripheral blood biomarkers of mTBI, as well as comment on the issues surrounding their clinical application and utility.

Keywords: biological mechanisms; chronic traumatic encephalopathy; diagnostic markers; high throughput; pathophysiology; peripheral blood; post-concussion syndrome; prognostic markers

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