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Tabatabaei-Malazy O, Fakhrzadeh H, Qorbani M, et al. Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes. J Diabetes Metab Disord. 2012;11(1):18doi: 10.1186/2251-6581-11-18.
Tabatabaei-Malazy, O., Fakhrzadeh, H., Qorbani, M., Amiri, P., Larijani, B., Tavakkoly-Bazzaz, J., & Amoli, M. M. (2012). Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes. Journal of diabetes and metabolic disorders, 11(1), 18. https://doi.org/10.1186/2251-6581-11-18
Tabatabaei-Malazy, Ozra, et al. "Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes." Journal of diabetes and metabolic disorders vol. 11,1 (2012): 18. doi: https://doi.org/10.1186/2251-6581-11-18
Tabatabaei-Malazy O, Fakhrzadeh H, Qorbani M, Amiri P, Larijani B, Tavakkoly-Bazzaz J, Amoli MM. Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes. J Diabetes Metab Disord. 2012 Oct 08;11(1):18. doi: 10.1186/2251-6581-11-18. PMID: 23497440; PMCID: PMC3598169.
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J Diabetes Metab Disord. 2012 Oct 08;11(1):18. doi: 10.1186/2251-6581-11-18.

Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes.

Journal of diabetes and metabolic disorders

Ozra Tabatabaei-Malazy, Hossein Fakhrzadeh, Mostafa Qorbani, Parvin Amiri, Bagher Larijani, Javad Tavakkoly-Bazzaz, Mahsa M Amoli

Affiliations

  1. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. [email protected].

PMID: 23497440 PMCID: PMC3598169 DOI: 10.1186/2251-6581-11-18

Abstract

BACKGROUND: Apolipoprotein E (apo E) plays a major role in lipid metabolism, obesity and accordingly in development of diabetes and coronary heart disease (CHD). Our main objective was to evaluate the association between apo E gene polymorphism with anthropometric measures.

METHODS: Participants were selected from zone 17 Tehran/Iran. We assessed height, weight, body mass index (BMI), waist circumference (WC), blood pressure, serum fasting blood sugar, total cholesterol and triglycerides. Genotyping for apo E gene polymorphism was carried out using PCR-RFLP technique.

RESULTS: Among total study population (n=311), 156 subjects were diabetic. The apo E3/E3 was the most common genotype in our population while E2 and E4 alleles had lower frequencies, respectively. After adjustment for diabetes, the apo E2 and E4 alleles were significantly associated with hypercholesterolemia and WC, respectively (p= 0.009, 0.034). This association was also related to sex and age. The probability of having abdominal obesity in E4 allele carriers was increased from 0.22 to 8.12 in women and to 3.08 in age ≥ 50 years.

CONCLUSIONS: Apo E polymorphism had significant influences on WC and total cholesterol level in patients with type 2 diabetes. This study highlights the importance of lifestyle modifications which may be more beneficial in hypercholesterolemic women carriers of E2 and E4 alleles concomitant central obesity.

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