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Genomics Inform. 2013 Mar;11(1):52-4. doi: 10.5808/GI.2013.11.1.52. Epub 2013 Mar 31.

Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family.

Genomics & informatics

Kyeongchae Cheong, Jaehyuk Choi, Jaeyoung Choi, Jongsun Park, Suwang Jang, Yong-Hwan Lee

Affiliations

  1. Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea. ; Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.

PMID: 23613683 PMCID: PMC3630386 DOI: 10.5808/GI.2013.11.1.52

Abstract

Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.

Keywords: HSP40 heat-shock proteins; HSP70 heat-shock proteins; database

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