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Park J, Jurcic JG, Rosenblat T, et al. Emerging new approaches for the treatment of acute promyelocytic leukemia. Ther Adv Hematol. 2011;2(5):335-52doi: 10.1177/2040620711410773.
Park, J., Jurcic, J. G., Rosenblat, T., & Tallman, M. S. (2011). Emerging new approaches for the treatment of acute promyelocytic leukemia. Therapeutic advances in hematology, 2(5), 335-52. https://doi.org/10.1177/2040620711410773
Park, Jae, et al. "Emerging new approaches for the treatment of acute promyelocytic leukemia." Therapeutic advances in hematology vol. 2,5 (2011): 335-52. doi: https://doi.org/10.1177/2040620711410773
Park J, Jurcic JG, Rosenblat T, Tallman MS. Emerging new approaches for the treatment of acute promyelocytic leukemia. Ther Adv Hematol. 2011 Oct;2(5):335-52. doi: 10.1177/2040620711410773. PMID: 23556100; PMCID: PMC3573416.
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Ther Adv Hematol. 2011 Oct;2(5):335-52. doi: 10.1177/2040620711410773.

Emerging new approaches for the treatment of acute promyelocytic leukemia.

Therapeutic advances in hematology

Jae Park, Joseph G Jurcic, Todd Rosenblat, Martin S Tallman

Affiliations

  1. Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.

PMID: 23556100 PMCID: PMC3573416 DOI: 10.1177/2040620711410773

Abstract

The introduction of all-trans retinoic acid (ATRA) in the late 1980s combined with anthracycline-based chemotherapy has revolutionized the prognosis of acute promyelocytic leukemia (APL) with more than 90% complete response rates and cure rates of approximately 80%. The subsequent advent of arsenic trioxide (ATO) in 1990s and progress in the treatment of APL have changed its course from a highly fatal to a highly curable disease. Despite the dramatic improvement in clinical outcome of APL, treatment failure still occurs due most often to early death. Relapse has become increasingly less frequent, most commonly occurring in patients with high-risk disease. A major focus of research for the past decade has been to develop risk-adapted and rationally targeted nonchemotherapy treatment strategies to reduce treatment-related morbidity and mortality to low- and intermediate-risk or older patients while targeting more intensive or alternative therapy to those patients at most risk of relapse. In this review, emerging new approaches to APL treatment with special emhasis on strategies to reduce early deaths, risk-adapted therapy during induction, consolidation and maintenance, as well as an overview of current and future clinical trials in APL will be discussed.

Keywords: acute promyelocytic leukemia

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