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Bartzatt R. Lomustine analogous drug structures for intervention of brain and spinal cord tumors: the benefit of in silico substructure search and analysis. Chemother Res Pract. 2013;2013:360624doi: 10.1155/2013/360624.
Bartzatt, R. (2013). Lomustine analogous drug structures for intervention of brain and spinal cord tumors: the benefit of in silico substructure search and analysis. Chemotherapy research and practice, 2013360624. https://doi.org/10.1155/2013/360624
Bartzatt, Ronald. "Lomustine analogous drug structures for intervention of brain and spinal cord tumors: the benefit of in silico substructure search and analysis." Chemotherapy research and practice vol. 2013 (2013): 360624. doi: https://doi.org/10.1155/2013/360624
Bartzatt R. Lomustine analogous drug structures for intervention of brain and spinal cord tumors: the benefit of in silico substructure search and analysis. Chemother Res Pract. 2013;2013:360624. doi: 10.1155/2013/360624. Epub 2013 Apr 16. PMID: 23691318; PMCID: PMC3652141.
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Chemother Res Pract. 2013;2013:360624. doi: 10.1155/2013/360624. Epub 2013 Apr 16.

Lomustine analogous drug structures for intervention of brain and spinal cord tumors: the benefit of in silico substructure search and analysis.

Chemotherapy research and practice

Ronald Bartzatt

Affiliations

  1. University of Nebraska, College of Arts & Sciences, Durham Science Center, 6001 Dodge Street, Omaha, NE 68182, USA.

PMID: 23691318 PMCID: PMC3652141 DOI: 10.1155/2013/360624

Abstract

Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma. In silico substructure searches produced 17 novel nitrosourea agents analogous to lumustine and retaining activity for DNA alkylation and cytotoxic activity. The mean values for Log P, polar surface area, formula weight, number of oxygens & nitrogens, and rotatable bonds were 2.524, 62.89 Anstroms(2), 232.8, 5, and 2, respectively. All 17 agents have formula weight less than 450 and Log P less than 5, two criteria preferred for blood-brain barrier penetration. These agents have a polar surface area less than 90 Angstroms(2). Each show zero violations of the Rule of five indicating favorable drug likeness and oral drug activity. Hierarchical cluster analysis indicated that 16 of the novel agents were highly similar to lomustine, save for agent 12 which bears a hydroxylated branched carbon substituent. A total of 17 novel anticancer agents were elucidated having molecular properties very effective for penetrating through the BBB and into the central nervous system. This study shows the effectiveness of in silico search and recognition of anticancer agents that are suitable for the clinical treatment of brain tumors.

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