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Nieder C, Spanne O, Haukland E, et al. Does Time between Imaging Diagnosis and Initiation of Radiotherapy Impact Survival after Whole-Brain Radiotherapy for Brain Metastases?. ISRN Oncol. 2013;2013:214304doi: 10.1155/2013/214304.
Nieder, C., Spanne, O., Haukland, E., & Dalhaug, A. (2013). Does Time between Imaging Diagnosis and Initiation of Radiotherapy Impact Survival after Whole-Brain Radiotherapy for Brain Metastases?. ISRN oncology, 2013214304. https://doi.org/10.1155/2013/214304
Nieder, Carsten, et al. "Does Time between Imaging Diagnosis and Initiation of Radiotherapy Impact Survival after Whole-Brain Radiotherapy for Brain Metastases?." ISRN oncology vol. 2013 (2013): 214304. doi: https://doi.org/10.1155/2013/214304
Nieder C, Spanne O, Haukland E, Dalhaug A. Does Time between Imaging Diagnosis and Initiation of Radiotherapy Impact Survival after Whole-Brain Radiotherapy for Brain Metastases?. ISRN Oncol. 2013 Apr 11;2013:214304. doi: 10.1155/2013/214304. Print 2013. PMID: 23691360; PMCID: PMC3649498.
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ISRN Oncol. 2013 Apr 11;2013:214304. doi: 10.1155/2013/214304. Print 2013.

Does Time between Imaging Diagnosis and Initiation of Radiotherapy Impact Survival after Whole-Brain Radiotherapy for Brain Metastases?.

ISRN oncology

Carsten Nieder, Oddvar Spanne, Ellinor Haukland, Astrid Dalhaug

Affiliations

  1. Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway ; Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway.

PMID: 23691360 PMCID: PMC3649498 DOI: 10.1155/2013/214304

Abstract

Aims. To evaluate whether reduced waiting time influences survival of patients treated with whole-brain radiotherapy (WBRT) for brain metastases. Materials and Methods. Retrospective intention-to-treat study including 110 patients treated with primary WBRT (typically 10 fractions of 3 Gy; no other treatment between diagnosis and WBRT). Uni- and multivariate tests were performed. Results. Median delay between imaging diagnosis and WBRT was 12 days (range 0-66 days). WBRT started within 1 week in 36%, during the second week in 28%, and during the third week in 18% of patients. No significant correlation between waiting time and survival was evident, except for one subgroup of patients. Those without extracranial metastases (potentially more threatened by worse intracranial disease control) survived for a median of 2.5 months from WBRT if waiting time was 2 weeks or longer as compared to 5.6 months if waiting time was shorter than 2 weeks (P = 0.03). The same correlation was seen if survival was computed from imaging diagnosis. Conclusion. If departmental resources are not sufficient to provide immediate WBRT within 2 weeks to all patients, those without extracranial metastases should be prioritised. This study did not address the impact of waiting time on quality of life or symptom palliation.

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