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Lehnen AM, Rodrigues B, Irigoyen MC, et al. Cardiovascular changes in animal models of metabolic syndrome. J Diabetes Res. 2013;2013:761314doi: 10.1155/2013/761314.
Lehnen, A. M., Rodrigues, B., Irigoyen, M. C., De Angelis, K., & Schaan, B. D. (2013). Cardiovascular changes in animal models of metabolic syndrome. Journal of diabetes research, 2013761314. https://doi.org/10.1155/2013/761314
Lehnen, Alexandre M, et al. "Cardiovascular changes in animal models of metabolic syndrome." Journal of diabetes research vol. 2013 (2013): 761314. doi: https://doi.org/10.1155/2013/761314
Lehnen AM, Rodrigues B, Irigoyen MC, De Angelis K, Schaan BD. Cardiovascular changes in animal models of metabolic syndrome. J Diabetes Res. 2013;2013:761314. doi: 10.1155/2013/761314. Epub 2013 Mar 14. PMID: 23691518; PMCID: PMC3647579.
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J Diabetes Res. 2013;2013:761314. doi: 10.1155/2013/761314. Epub 2013 Mar 14.

Cardiovascular changes in animal models of metabolic syndrome.

Journal of diabetes research

Alexandre M Lehnen, Bruno Rodrigues, Maria Cláudia Irigoyen, Kátia De Angelis, Beatriz D'Agord Schaan

Affiliations

  1. Laboratório de Experimentação Animal e Laboratório de Cardiologia Celular e Molecular, Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil ; Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

PMID: 23691518 PMCID: PMC3647579 DOI: 10.1155/2013/761314

Abstract

Metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes. Insulin resistance seems to have a fundamental role in the genesis of this syndrome. Over the past years to the present day, basic and translational research has used small animal models to explore the pathophysiology of metabolic syndrome and to develop novel therapies that might slow the progression of this prevalent condition. In this paper we discuss the animal models used for the study of metabolic syndrome, with particular focus on cardiovascular changes, since they are the main cause of death associated with the condition in humans.

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