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Im S, Choi HJ, Yoo C, et al. Hedgehog related protein expression in breast cancer: gli-2 is associated with poor overall survival. Korean J Pathol. 2013;47(2):116-23doi: 10.4132/KoreanJPathol.2013.47.2.116.
Im, S., Choi, H. J., Yoo, C., Jung, J. H., Jeon, Y. W., Suh, Y. J., & Kang, C. S. (2013). Hedgehog related protein expression in breast cancer: gli-2 is associated with poor overall survival. Korean journal of pathology, 47(2), 116-23. https://doi.org/10.4132/KoreanJPathol.2013.47.2.116
Im, Soyoung, et al. "Hedgehog related protein expression in breast cancer: gli-2 is associated with poor overall survival." Korean journal of pathology vol. 47,2 (2013): 116-23. doi: https://doi.org/10.4132/KoreanJPathol.2013.47.2.116
Im S, Choi HJ, Yoo C, Jung JH, Jeon YW, Suh YJ, Kang CS. Hedgehog related protein expression in breast cancer: gli-2 is associated with poor overall survival. Korean J Pathol. 2013 Apr;47(2):116-23. doi: 10.4132/KoreanJPathol.2013.47.2.116. Epub 2013 Apr 24. PMID: 23667370; PMCID: PMC3647123.
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Korean J Pathol. 2013 Apr;47(2):116-23. doi: 10.4132/KoreanJPathol.2013.47.2.116. Epub 2013 Apr 24.

Hedgehog related protein expression in breast cancer: gli-2 is associated with poor overall survival.

Korean journal of pathology

Soyoung Im, Hyun Joo Choi, Changyoung Yoo, Ji-Han Jung, Ye-Won Jeon, Young Jin Suh, Chang Suk Kang

Affiliations

  1. Department of Hospital Pathology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.

PMID: 23667370 PMCID: PMC3647123 DOI: 10.4132/KoreanJPathol.2013.47.2.116

Abstract

BACKGROUND: The hedgehog (Hh) signaling pathway is known to play a critical role in various malignancies, but its clinicopathologic role in breast cancer is yet to be established.

METHODS: Tissue microarray blocks from 334 cases of breast cancer were prepared. The expression of six Hh signaling proteins including sonic hedgehog (Shh), patched (Ptch), smoothened (Smo), and the glioma-associated oncogene (Gli)-1, Gli-2, and Gli-3 were analyzed immunohistochemically.

RESULTS: The expression of Hh signaling proteins was significantly correlated with some prognostic factors including the correlation of lymph node metastasis with the expression of Shh (p=0.001) and Ptch (p=0.064), the correlation of the stages with Shh and Gli-3 expression (p=0.007 and p=0.024, respectively), the correlation of the nuclear grade with the Smo (p=0.004) and Gli-3 (p=0.000), and the correlation of the histologic grade with the Ptch (p=0.016), Smo (p=0.007), and Gli-3 (p=0.000). The Shh, Ptch, Smo, Gli-1, and Gli-2 expression was significantly different between the phenotypes (p=0.000, p=0.001, p=0.004, p=0.039, and p=0.031, respectively). Gli-2 expression was correlated with a worse overall survival outcome (p=0.012).

CONCLUSIONS: Hh pathway activation is correlated with a more aggressive clinical behavior in breast carcinomas. The comparison of phenotypes suggested that the Hh pathway may be a useful therapeutic target for breast carcinoma. Patients with Gli-2 expression had a significantly lower overall survival rate and, therefore, it showed promise as a prognostic marker.

Keywords: Breast neoplasms; Gli protein; Gli-2 protein; Hedgehog proteins

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