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Korean J Pathol. 2013 Apr;47(2):182-7. doi: 10.4132/KoreanJPathol.2013.47.2.182. Epub 2013 Apr 24.

ThinPrep Cytological Findings of Desmoplastic Small Round Cell Tumor with Extensive Glandular Differentiation: A Case Study.

Korean journal of pathology

Hyun-Jung Kim, Byeong Seok Sohn, Ji-Eun Kwon, Jeong Yeon Kim, Kyeongmee Park

Affiliations

  1. Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

PMID: 23667380 PMCID: PMC3647133 DOI: 10.4132/KoreanJPathol.2013.47.2.182

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of this tumor has only been reported in a few cases. In most of these cases, the diagnosis was made using fine-needle aspiration cytology. Most DSRCTs resemble disseminated carcinomatoses in their clinical manifestation as well as cytomorphologically, even in young-adult patients. These authors report a case of using peritoneal-washing and pleural-effusion ThinPrep cytology to diagnose DSRCT, with extensive glandular differentiation and mucin vacuoles. We found that fibrillary stromal fragment, clinical setting, and adjunctive immunocytochemical staining were most helpful for avoiding misdiagnosis.

Keywords: Desmin; Desmoplastic small round cell tumor; Gland; Mucin content; ThinPrep

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