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Demedts I, Masaoka T, Kindt S, et al. Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. J Neurogastroenterol Motil. 2013;19(2):161-70doi: 10.5056/jnm.2013.19.2.161.
Demedts, I., Masaoka, T., Kindt, S., De Hertogh, G., Geboes, K., Farré, R., Vanden Berghe, P., & Tack, J. (2013). Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. Journal of neurogastroenterology and motility, 19(2), 161-70. https://doi.org/10.5056/jnm.2013.19.2.161
Demedts, Ingrid, et al. "Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats." Journal of neurogastroenterology and motility vol. 19,2 (2013): 161-70. doi: https://doi.org/10.5056/jnm.2013.19.2.161
Demedts I, Masaoka T, Kindt S, De Hertogh G, Geboes K, Farré R, Vanden Berghe P, Tack J. Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats. J Neurogastroenterol Motil. 2013 Apr;19(2):161-70. doi: 10.5056/jnm.2013.19.2.161. Epub 2013 Apr 16. PMID: 23667747; PMCID: PMC3644652.
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J Neurogastroenterol Motil. 2013 Apr;19(2):161-70. doi: 10.5056/jnm.2013.19.2.161. Epub 2013 Apr 16.

Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats.

Journal of neurogastroenterology and motility

Ingrid Demedts, Tatsuhiro Masaoka, Sebastien Kindt, Gert De Hertogh, Karel Geboes, Ricard Farré, Pieter Vanden Berghe, Jan Tack

Affiliations

  1. Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.

PMID: 23667747 PMCID: PMC3644652 DOI: 10.5056/jnm.2013.19.2.161

Abstract

BACKGROUND/AIMS: Type 1 diabetes is often accompanied by gastrointestinal motility disturbances. Vagal neuropathy, hyperglycemia, and alterations in the myenteric plexus have been proposed as underlying mechanism. We therefore studied the relationship between vagal function, gastrointestinal motiliy and characteristics of the enteric nervous system in the biobreeding (BB) rat known as model for spontaneous type 1 diabetes.

METHODS: Gastric emptying breath test, small intestinal electromyography, relative risk-interval variability, histology and immunohistochemistry on antral and jejunal segments were performed at 1, 8 and 16 weeks after diabetes onset and on age-matched controls.

RESULTS: We observed no consistent changes in relative risk-interval variability and gastric emptying rate. There was however, a loss of phases 3 with longer duration of diabetes on small intestinal electromyography. We found a progressive decrease of nitrergic neurons in the myenteric plexus of antrum and jejunum, while numbers of cholinergic nerve were not altered. In addition, a transient inflammatory infiltrate in jejunal wall was found in spontaneous diabetic BB rats at 8 weeks of diabetes.

CONCLUSIONS: In diabetic BB rats, altered small intestinal motor control associated with a loss of myenteric nitric oxide synthase expression occurs, which does not depend on hyperglycemia or vagal dysfunction, and which is preceded by transient intestinal inflammation.

Keywords: Diabetes mellitus; Electromyography; Enteric nervous system; Gastric empyting; Rats, inbred BB

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