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Nonaka T, Sekino Y, Iida H, et al. Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test. J Neurogastroenterol Motil. 2013;19(2):227-32doi: 10.5056/jnm.2013.19.2.227.
Nonaka, T., Sekino, Y., Iida, H., Yamada, E., Ohkubo, H., Sakai, E., Higurashi, T., Hosono, K., Endo, H., Koide, T., Takahashi, H., Fujita, K., Yoneda, M., Goto, A., Kusakabe, A., Kobayashi, N., Gotoh, E., Maeda, S., Nakajima, A., Nosaka, C., & Inamori, M. (2013). Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test. Journal of neurogastroenterology and motility, 19(2), 227-32. https://doi.org/10.5056/jnm.2013.19.2.227
Nonaka, Takashi, et al. "Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test." Journal of neurogastroenterology and motility vol. 19,2 (2013): 227-32. doi: https://doi.org/10.5056/jnm.2013.19.2.227
Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi T, Hosono K, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi N, Gotoh E, Maeda S, Nakajima A, Nosaka C, Inamori M. Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test. J Neurogastroenterol Motil. 2013 Apr;19(2):227-32. doi: 10.5056/jnm.2013.19.2.227. Epub 2013 Apr 16. PMID: 23667754; PMCID: PMC3644659.
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J Neurogastroenterol Motil. 2013 Apr;19(2):227-32. doi: 10.5056/jnm.2013.19.2.227. Epub 2013 Apr 16.

Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test.

Journal of neurogastroenterology and motility

Takashi Nonaka, Yusuke Sekino, Hiroshi Iida, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takuma Higurashi, Kunihiro Hosono, Hiroki Endo, Tomoko Koide, Hirokazu Takahashi, Koji Fujita, Masato Yoneda, Ayumu Goto, Akihiko Kusakabe, Noritoshi Kobayashi, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Chihiro Nosaka, Masahiko Inamori

Affiliations

  1. Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan.

PMID: 23667754 PMCID: PMC3644659 DOI: 10.5056/jnm.2013.19.2.227

Abstract

BACKGROUND/AIMS: The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the (13)C-acetic acid breath test.

METHODS: Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg (13)C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and κ), calculated by using the (13)CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically.

RESULTS: No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and κ, were observed between the 2 test conditions.

CONCLUSIONS: The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.

Keywords: Breath tests; Gastric emptying; Sitagliptin

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