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Doescher A, Müller TH. Noninvasive pH Monitoring in Platelet Concentrates. Transfus Med Hemother. 2013;40(2):88-92doi: 10.1159/000350220.
Doescher, A., & Müller, T. H. (2013). Noninvasive pH Monitoring in Platelet Concentrates. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 40(2), 88-92. https://doi.org/10.1159/000350220
Doescher, Andrea, and Müller, Thomas H. "Noninvasive pH Monitoring in Platelet Concentrates." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 40,2 (2013): 88-92. doi: https://doi.org/10.1159/000350220
Doescher A, Müller TH. Noninvasive pH Monitoring in Platelet Concentrates. Transfus Med Hemother. 2013 Apr;40(2):88-92. doi: 10.1159/000350220. Epub 2013 Mar 14. PMID: 23652541; PMCID: PMC3638934.
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Transfus Med Hemother. 2013 Apr;40(2):88-92. doi: 10.1159/000350220. Epub 2013 Mar 14.

Noninvasive pH Monitoring in Platelet Concentrates.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Andrea Doescher, Thomas H Müller

Affiliations

  1. DRK-Blutspendedienst NSTOB, Institut Bremen-Oldenburg, Oldenburg, Springe, Germany.

PMID: 23652541 PMCID: PMC3638934 DOI: 10.1159/000350220

Abstract

BACKGROUND: New technology introduces the option to measure pH in platelet concentrates noninvasively. Findings that in one out of 25 apheresis concentrates the pH decreased significantly during storage motivated us to evaluate apheresis concentrates from 307 platelet donors.

METHODS: Small (15 ml) BSCI storage containers for noninvasive pH measurement were used in parallel with Fenwal PL2400 bags for storage of 5 days. Noninvasive pH measurement was compared to pH determination in samples from the storage container. Decrease of pH during storage was calculated as ΔpH d2-d5.

RESULTS: The coefficient of correlation for noninvasive pH measurement (n = 256) versus standard methods was R(2) = 0.964 (pH electrode) or 0.952 (ABL 510). pH values in BSCI bags were slightly lower than in Fenwal PL2400 containers. Concentrates collected from 8 of the 307 donors showed a significant drop in pH. Repeated collection did not confirm these findings with a single exception.

CONCLUSION: Noninvasive pH measurement demonstrates a high reproducibility. Our study could not confirm the frequency of 1 out of 25 plateletpheresis donors with concentrates developing a significant drop in pH during storage. This may be due to a substantially lower platelet concentration in our preparations.

Keywords: Donor screening; Noninvasive pH measurement; Platelet concentrates

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