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Pixley JS, Zanjani ED. In utero transplantation: Disparate ramifications. World J Stem Cells. 2013;5(2):43-52doi: 10.4252/wjsc.v5.i2.43.
Pixley, J. S., & Zanjani, E. D. (2013). In utero transplantation: Disparate ramifications. World journal of stem cells, 5(2), 43-52. https://doi.org/10.4252/wjsc.v5.i2.43
Pixley, John S, and Zanjani, Esmail D. "In utero transplantation: Disparate ramifications." World journal of stem cells vol. 5,2 (2013): 43-52. doi: https://doi.org/10.4252/wjsc.v5.i2.43
Pixley JS, Zanjani ED. In utero transplantation: Disparate ramifications. World J Stem Cells. 2013 Apr 26;5(2):43-52. doi: 10.4252/wjsc.v5.i2.43. PMID: 23671718; PMCID: PMC3648645.
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World J Stem Cells. 2013 Apr 26;5(2):43-52. doi: 10.4252/wjsc.v5.i2.43.

In utero transplantation: Disparate ramifications.

World journal of stem cells

John S Pixley, Esmail D Zanjani

Affiliations

  1. John S Pixley, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, Reno, NV 89557, United States.

PMID: 23671718 PMCID: PMC3648645 DOI: 10.4252/wjsc.v5.i2.43

Abstract

In utero stem cell transplantation, which promises treatment for a host of genetic disorders early in gestation before disease effect stems from Ray Owen's seminal observation that self-tolerance, is acquired during gestation. To date, in utero transplantation (IUT) has proved useful in characterizing the hematopoietic stem cell. Recent observations support its use as an in vivo method to further understanding of self-tolerance. Preclinical development continues for its application as a treatment for childhood hematolymphoid diseases. In addition, IUT may offer therapeutic options in the treatment of diabetes among other diseases. Thus IUT serves as a technique or system important in both a basic and applied format. This review summarizes these findings.

Keywords: Immune ontogeny; Self non-self discrimination; Stem cell transplantation

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