Korean J Fam Med. 2013 May;34(3):199-205. doi: 10.4082/kjfm.2013.34.3.199. Epub 2013 May 24.

Non-alcoholic Fatty Liver Disease and Chronic Kidney Disease in Koreans Aged 50 Years or Older.

Korean journal of family medicine

Ah-Leum Ahn, Jae-Kyung Choi, Mi-Na Kim, Seun-Ah Kim, Eun-Jung Oh, Hyuk-Jung Kweon, Dong-Yung Cho

PMID: 23730487 PMCID: PMC3667227 DOI: 10.4082/kjfm.2013.34.3.199

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older.

METHODS: A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate ≤60 mL/min per 1.73 m(2).

RESULTS: Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, γ-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus.

CONCLUSION: NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.

Keywords: Chronic Renal Insufficiency; Glomerular Filtration Rate; Non-alcoholic Fatty Liver Disease; Proteinuria; Ultrasonography

References

1. Nat Rev Nephrol. 2009 Dec;5(12):677-89 - PubMed
2. Ann Epidemiol. 2007 Nov;17(11):863-9 - PubMed
3. Hepatology. 1999 Dec;30(6):1356-62 - PubMed
4. Hypertens Res. 2012 Feb;35(2):142-7 - PubMed
5. Semin Thromb Hemost. 2009 Apr;35(3):277-87 - PubMed
6. J Am Soc Nephrol. 2008 Aug;19(8):1564-70 - PubMed
7. Clin Chem. 2005 Jul;51(7):1185-91 - PubMed
8. N Engl J Med. 2006 Jun 8;354(23):2473-83 - PubMed
9. Adv Chronic Kidney Dis. 2010 Jul;17(4):293-301 - PubMed
10. Clin Chem. 2007 Jan;53(1):71-7 - PubMed
11. Intern Med J. 2010 Jun;40(6):437-42 - PubMed
12. JAMA. 2001 May 16;285(19):2486-97 - PubMed
13. Gastroenterology. 2002 Sep;123(3):745-50 - PubMed
14. Metabolism. 2008 Apr;57(4):569-76 - PubMed
15. Circulation. 2003 Oct 28;108(17):2154-69 - PubMed
16. Diabetologia. 2010 Jul;53(7):1341-8 - PubMed
17. Diabet Med. 2006 Apr;23(4):403-9 - PubMed
18. Am J Gastroenterol. 2009 Sep;104(9):2182-8 - PubMed
19. Gastroenterology. 2007 May;132(6):2103-15 - PubMed
20. Internist (Berl). 2007 Feb;48(2):154-63 - PubMed
21. J Gastroenterol Hepatol. 2002 Nov;17(11):1136-43 - PubMed
22. J Hepatol. 2008;48 Suppl 1:S104-12 - PubMed
23. Korean J Hepatol. 2009 Dec;15 Suppl 6:S34-9 - PubMed
24. Hepatology. 2009 Jan;49(1):306-17 - PubMed
25. J Gastroenterol. 2007 Jul;42(7):573-82 - PubMed
26. Am J Gastroenterol. 2010 Jan;105(1):14-32; quiz 33 - PubMed
27. CMAJ. 2005 Mar 29;172(7):899-905 - PubMed
28. J Hepatol. 2011 May;54(5):1020-9 - PubMed
29. Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):583-90 - PubMed

Publication Types

• Journal Article