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Ejiofor S, Turner AM. Pharmacotherapies for COPD. Clin Med Insights Circ Respir Pulm Med. 2013;7:17-34doi: 10.4137/CCRPM.S7211.
Ejiofor, S., & Turner, A. M. (2013). Pharmacotherapies for COPD. Clinical medicine insights. Circulatory, respiratory and pulmonary medicine, 717-34. https://doi.org/10.4137/CCRPM.S7211
Ejiofor, Stan, and Turner, Alice M. "Pharmacotherapies for COPD." Clinical medicine insights. Circulatory, respiratory and pulmonary medicine vol. 7 (2013): 17-34. doi: https://doi.org/10.4137/CCRPM.S7211
Ejiofor S, Turner AM. Pharmacotherapies for COPD. Clin Med Insights Circ Respir Pulm Med. 2013 Apr 25;7:17-34. doi: 10.4137/CCRPM.S7211. Print 2013. PMID: 23700381; PMCID: PMC3653890.
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Clin Med Insights Circ Respir Pulm Med. 2013 Apr 25;7:17-34. doi: 10.4137/CCRPM.S7211. Print 2013.

Pharmacotherapies for COPD.

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine

Stan Ejiofor, Alice M Turner

Affiliations

  1. Russells Hall Hospital, Dudley, West Midlands, UK.

PMID: 23700381 PMCID: PMC3653890 DOI: 10.4137/CCRPM.S7211

Abstract

This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their use. Drug classes covered were short acting beta agonists (SABA), short acting muscarinic antagonists (SAMA), long acting beta agonists (LABA), long acting antimuscarinics (LAMA), inhaled corticosteroids (ICS), LABA/ICS combinations, specific phosphodiesterase (PDE4) inhibitors, non-specific PDE inhibitors, mucolytics, and oxygen. Non-specific therapies, such as opiates for relief of dyspnoea and therapies for smoking cessation, are also covered briefly. For each class of drug, mechanisms of action are described, key clinical trial results are reported, and available agents compared. Finally, the place of each drug in therapy is compared between current worldwide guidelines.

Keywords: chronic obstructive pulmonary disease; disease management; pharmacotherapies

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