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Chem Cent J. 2013 Jun 03;7(1):95. doi: 10.1186/1752-153X-7-95.

Quinazoline derivatives: synthesis and bioactivities.

Chemistry Central journal

Dan Wang, Feng Gao

Affiliations

  1. Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agricultural University, No, 211, Huiming Road, Wenjiang Region, Chengdu, 611130, P, R, China. [email protected].

PMID: 23731671 PMCID: PMC3679743 DOI: 10.1186/1752-153X-7-95

Abstract

Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design, those synthetic methods were divided into five main classifications, including Aza-reaction, Microwave-assisted reaction, Metal-mediated reaction, Ultrasound-promoted reaction and Phase-transfer catalysis reaction. The biological activities of the synthesized quinazoline derivatives also are discussed.

References

  1. Eur J Med Chem. 2004 Jan;39(1):59-67 - PubMed
  2. Org Lett. 2012 Jul 20;14(14):3800-3 - PubMed
  3. J Clin Invest. 1988 Sep;82(3):1134-43 - PubMed
  4. J Med Chem. 1996 Dec 20;39(26):5176-82 - PubMed
  5. Chem Rev. 2008 Dec;108(12):5359-406 - PubMed
  6. J Med Chem. 1995 Sep 1;38(18):3482-7 - PubMed
  7. Biol Pharm Bull. 2002 Nov;25(11):1432-5 - PubMed
  8. J Med Chem. 1968 Jan;11(1):130-6 - PubMed
  9. J Comb Chem. 2007 Nov-Dec;9(6):1144-8 - PubMed
  10. Eur J Med Chem. 2008 Nov;43(11):2323-30 - PubMed
  11. J Med Chem. 2002 Jul 4;45(14):3057-66 - PubMed
  12. Cancer Res. 2002 Oct 15;62(20):5749-54 - PubMed
  13. Eur J Med Chem. 2013 Mar;61:84-94 - PubMed
  14. Cell Regul. 1990 Jul;1(8):555-66 - PubMed
  15. J Clin Invest. 1994 Oct;94(4):1563-9 - PubMed
  16. Lab Invest. 1991 Aug;65(2):160-7 - PubMed
  17. Eur J Med Chem. 2009 Jul;44(7):3046-55 - PubMed
  18. Biol Pharm Bull. 2003 Dec;26(12):1711-4 - PubMed
  19. J Exp Med. 1992 May 1;175(5):1413-6 - PubMed
  20. Eur J Med Chem. 2008 Jan;43(1):160-5 - PubMed
  21. Am J Physiol. 1998 Jan;274(1):L72-80 - PubMed
  22. J Med Chem. 2006 Feb 23;49(4):1475-85 - PubMed
  23. Eur J Med Chem. 2009 Mar;44(3):1188-97 - PubMed
  24. Bioorg Med Chem. 2009 Feb 15;17(4):1648-53 - PubMed
  25. Bioorg Med Chem. 2006 May 15;14(10):3307-19 - PubMed
  26. Eur J Med Chem. 2010 Mar;45(3):1200-5 - PubMed
  27. Mol Divers. 2012 Aug;16(3):579-90 - PubMed
  28. Int J Mol Sci. 2012;13(6):6730-46 - PubMed
  29. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6 - PubMed
  30. Int J Mol Sci. 2010 Oct 25;11(10):4165-74 - PubMed
  31. Gen Pharmacol. 1998 Nov;31(5):765-73 - PubMed
  32. Biochem Pharmacol. 1994 Aug 17;48(4):659-66 - PubMed
  33. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7 - PubMed
  34. Science. 1994 Aug 19;265(5175):1093-5 - PubMed
  35. Boll Chim Farm. 1995 Dec;134(11):609-15 - PubMed
  36. Org Lett. 2012 Aug 3;14(15):3894-7 - PubMed
  37. Eur J Med Chem. 2009 Aug;44(8):3330-9 - PubMed
  38. Chem Biodivers. 2006 Jan;3(1):106-17 - PubMed
  39. J Am Chem Soc. 1974 Jul 10;96(14):4708-9 - PubMed
  40. Bioorg Med Chem Lett. 2012 May 1;22(9):3157-62 - PubMed
  41. J Pharmacol Exp Ther. 2005 May;313(2):831-9 - PubMed
  42. Arch Pharm (Weinheim). 2003 Dec;336(12):560-6 - PubMed
  43. J Med Chem. 1991 Apr;34(4):1492-503 - PubMed
  44. J Med Chem. 1996 Feb 16;39(4):918-28 - PubMed
  45. Bioorg Med Chem. 2007 Jan 1;15(1):235-41 - PubMed
  46. Science. 1990 May 25;248(4958):1009-12 - PubMed
  47. Chem Commun (Camb). 2012 Apr 21;48(32):3836-8 - PubMed
  48. J Med Chem. 1999 May 20;42(10):1803-15 - PubMed
  49. J Biol Chem. 2000 Jan 28;275(4):2247-50 - PubMed
  50. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6301-5 - PubMed
  51. Biol Pharm Bull. 2004 May;27(5):652-6 - PubMed
  52. Bioorg Med Chem. 2006 Dec 15;14(24):8608-21 - PubMed
  53. Biol Pharm Bull. 2003 Apr;26(4):557-9 - PubMed
  54. Eur J Med Chem. 2003 Feb;38(2):123-40 - PubMed
  55. Arzneimittelforschung. 1993 May;43(5):595-600 - PubMed
  56. Chem Pharm Bull (Tokyo). 2009 Jun;57(6):580-5 - PubMed
  57. Indian J Pharm Sci. 2010 May;72(3):375-8 - PubMed
  58. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6560-4 - PubMed
  59. Cancer. 1994 Sep 15;74(6):1693-8 - PubMed
  60. Folia Microbiol (Praha). 2005;50(2):90-4 - PubMed
  61. Org Lett. 2012 Mar 16;14(6):1420-3 - PubMed
  62. Eur J Med Chem. 2003 Jan;38(1):101-7 - PubMed
  63. Eur J Med Chem. 2012 Aug;54:925-30 - PubMed
  64. Org Lett. 2007 Jan 4;9(1):69-72 - PubMed
  65. J Med Chem. 1982 Oct;25(10):1261-4 - PubMed
  66. Am J Pathol. 1999 Jul;155(1):213-21 - PubMed
  67. Curr Top Med Chem. 2004;4(7):773-92 - PubMed
  68. J Med Chem. 1996 Jan 5;39(1):267-76 - PubMed
  69. Chem Rev. 2001 Aug;101(8):2541-72 - PubMed
  70. Org Biomol Chem. 2011 Mar 7;9(5):1429-36 - PubMed
  71. Eur J Med Chem. 2005 Aug;40(8):816-9 - PubMed

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