Chem Cent J. 2013 Jun 03;7(1):95. doi: 10.1186/1752-153X-7-95.
Chemistry Central journal
Dan Wang, Feng Gao
PMID: 23731671 PMCID: PMC3679743 DOI: 10.1186/1752-153X-7-95
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design, those synthetic methods were divided into five main classifications, including Aza-reaction, Microwave-assisted reaction, Metal-mediated reaction, Ultrasound-promoted reaction and Phase-transfer catalysis reaction. The biological activities of the synthesized quinazoline derivatives also are discussed.