Display options
Cite
Lone AM, Taskén K. Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Front Immunol. 2013;4:130doi: 10.3389/fimmu.2013.00130.
Lone, A. M., & Taskén, K. (2013). Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Frontiers in immunology, 4130. https://doi.org/10.3389/fimmu.2013.00130
Lone, Anna Mari, and Taskén, Kjetil. "Proinflammatory and immunoregulatory roles of eicosanoids in T cells." Frontiers in immunology vol. 4 (2013): 130. doi: https://doi.org/10.3389/fimmu.2013.00130
Lone AM, Taskén K. Proinflammatory and immunoregulatory roles of eicosanoids in T cells. Front Immunol. 2013 Jun 04;4:130. doi: 10.3389/fimmu.2013.00130. eCollection 2013. PMID: 23760108; PMCID: PMC3671288.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2013 Jun 04;4:130. doi: 10.3389/fimmu.2013.00130. eCollection 2013.

Proinflammatory and immunoregulatory roles of eicosanoids in T cells.

Frontiers in immunology

Anna Mari Lone, Kjetil Taskén

Affiliations

  1. Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital , Oslo , Norway ; Biotechnology Centre, University of Oslo , Oslo , Norway ; K.G. Jebsen Inflammation Research Centre, University of Oslo , Oslo , Norway.

PMID: 23760108 PMCID: PMC3671288 DOI: 10.3389/fimmu.2013.00130

Abstract

Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs), and thromboxanes (TXAs). The rate-limiting and tightly regulated lipoxygenases control synthesis of LTs while the equally well-controlled cyclooxygenases 1 and 2 generate prostanoids, including PGs, PCs, and TXAs. While many of the classical signs of inflammation such as redness, swelling, pain, and heat are caused by eicosanoid species with vasoactive, pyretic, and pain-inducing effects locally, some eicosanoids also regulate T cell functions. Here, we will review eicosanoid production in T cell subsets and the inflammatory and immunoregulatory functions of LTs, PGs, PCs, and TXAs in T cells.

Keywords: cAMP; cyclooxygenase 2; immunoregulation effect; inflammation; inflammation mediators; leukotrienes; prostaglandins; regulatory T cells

References

  1. J Immunol. 2000 Feb 1;164(3):1364-71 - PubMed
  2. Eur J Immunol. 1993 Oct;23(10):2392-8 - PubMed
  3. J Pharmacol Exp Ther. 2000 May;293(2):410-6 - PubMed
  4. Eur J Immunol. 1988 Nov;18(11):1791-6 - PubMed
  5. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3355-8 - PubMed
  6. J Immunol. 2005 Jul 15;175(2):713-9 - PubMed
  7. J Immunol. 2012 Jan 15;188(2):694-702 - PubMed
  8. J Exp Med. 1993 Nov 1;178(5):1825-30 - PubMed
  9. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11685-90 - PubMed
  10. Clin Exp Allergy. 1999 Nov;29(11):1532-6 - PubMed
  11. Chem Rev. 2011 Oct 12;111(10):5821-65 - PubMed
  12. Ann Rheum Dis. 2012 Dec;71(12):2044-50 - PubMed
  13. Med Res Rev. 2007 Jul;27(4):435-68 - PubMed
  14. Biochem Pharmacol. 2007 Mar 15;73(6):843-53 - PubMed
  15. J Immunol. 2002 Jul 15;169(2):802-8 - PubMed
  16. Semin Immunol. 2002 Feb;14(1):49-55 - PubMed
  17. J Exp Med. 2009 Mar 16;206(3):535-48 - PubMed
  18. Mediators Inflamm. 2012;2012:503128 - PubMed
  19. Clin Exp Allergy. 2001 Nov;31(11):1714-23 - PubMed
  20. Am J Physiol. 1999 Dec;277(6):R1741-8 - PubMed
  21. J Biol Chem. 2000 Feb 18;275(7):4541-4 - PubMed
  22. Mol Cancer. 2011 Dec 15;10:149 - PubMed
  23. Cell Immunol. 1990 Jul;128(2):385-9 - PubMed
  24. J Biochem Mol Toxicol. 2001;15(4):187-96 - PubMed
  25. Allergy. 2008 Feb;63(2):168-75 - PubMed
  26. Cell Signal. 2011 Jun;23(6):1009-16 - PubMed
  27. J Immunol. 2006 Jul 1;177(1):246-54 - PubMed
  28. Eur J Immunol. 2001 Apr;31(4):1098-105 - PubMed
  29. J Immunol. 1987 Sep 15;139(6):2075-80 - PubMed
  30. Biochim Biophys Acta. 1999 Jul 30;1439(2):121-33 - PubMed
  31. Biochem J. 1989 Apr 15;259(2):315-24 - PubMed
  32. Nat Immunol. 2003 Oct;4(10):982-90 - PubMed
  33. Science. 2001 Nov 30;294(5548):1871-5 - PubMed
  34. Blood. 2008 Nov 1;112(9):3696-703 - PubMed
  35. Transplantation. 1992 Sep;54(3):498-505 - PubMed
  36. J Exp Med. 2009 Oct 26;206(11):2543-55 - PubMed
  37. Eur J Pharmacol. 2003 Apr 11;466(1-2):169-80 - PubMed
  38. J Immunol. 1985 Aug;135(2):1172-9 - PubMed
  39. Am J Pathol. 2006 Oct;169(4):1183-93 - PubMed
  40. J Exp Med. 1994 Nov 1;180(5):1967-72 - PubMed
  41. Carcinogenesis. 2009 Mar;30(3):377-86 - PubMed
  42. J Immunol. 2007 Oct 15;179(8):5159-68 - PubMed
  43. Blood. 2010 Sep 30;116(13):2253-65 - PubMed
  44. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):27-36 - PubMed
  45. Cancer Metastasis Rev. 2007 Dec;26(3-4):525-34 - PubMed
  46. PLoS One. 2012;7(5):e33518 - PubMed
  47. Biochem Cell Biol. 2004 Feb;82(1):1-17 - PubMed
  48. Clin Exp Immunol. 2009 Apr;156(1):126-33 - PubMed
  49. Cell. 1995 Dec 1;83(5):813-9 - PubMed
  50. Annu Rev Pharmacol Toxicol. 2001;41:661-90 - PubMed
  51. J Allergy Clin Immunol. 2012 Apr;129(4):1136-42 - PubMed
  52. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5179-84 - PubMed
  53. J Pharmacol Exp Ther. 1996 Jun;277(3):1793-800 - PubMed
  54. J Immunol. 1987 Aug 15;139(4):1179-84 - PubMed
  55. Eur J Immunol. 1995 Apr;25(4):1080-6 - PubMed
  56. Eur J Immunol. 2009 May;39(5):1301-12 - PubMed
  57. Br J Pharmacol. 2012 May;166(2):411-9 - PubMed
  58. J Immunol. 2004 Aug 1;173(3):1503-10 - PubMed
  59. J Clin Invest. 2001 Jul;108(1):15-23 - PubMed
  60. J Immunol. 2009 Jun 15;182(12):7580-6 - PubMed
  61. J Clin Invest. 2001 Oct;108(8):1229-35 - PubMed
  62. Retrovirology. 2012 Jan 11;9:4 - PubMed
  63. J Biol Chem. 2000 Nov 17;275(46):35692-8 - PubMed
  64. Immunol Cell Biol. 2012 Jul;90(6):579-86 - PubMed
  65. J Clin Invest. 1987 Aug;80(2):333-40 - PubMed
  66. Immunology. 2007 Oct;122(2):157-66 - PubMed
  67. J Immunol. 2008 Jan 15;180(2):783-92 - PubMed
  68. Eur J Immunol. 1999 Jul;29(7):2360-5 - PubMed
  69. J Immunol. 1985 Feb;134(2):1125-9 - PubMed
  70. Nat Immunol. 2003 Jul;4(7):694-701 - PubMed
  71. Dev Immunol. 1992;2(4):263-71 - PubMed
  72. Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):87-101 - PubMed
  73. J Immunol. 1985 Aug;135(2):1357-60 - PubMed
  74. J Immunol. 1995 Feb 1;154(3):1041-7 - PubMed
  75. FEBS Lett. 2002 Jun 5;520(1-3):111-6 - PubMed
  76. Nat Med. 2009 Jun;15(6):633-40 - PubMed
  77. Annu Rev Biochem. 2000;69:145-82 - PubMed
  78. Clin Exp Allergy. 2012 Sep;42(9):1313-20 - PubMed
  79. Blood. 2006 Jan 15;107(2):444-53 - PubMed
  80. Immunobiology. 2000 Apr;201(5):493-505 - PubMed
  81. J Allergy Clin Immunol. 2009 Sep;124(3):406-14; quiz 415-6 - PubMed
  82. J Allergy Clin Immunol. 2012 Feb;129(2):492-500, 500.e1-9 - PubMed
  83. J Virol. 2011 Jul;85(13):6557-66 - PubMed
  84. Int Immunopharmacol. 2003 Oct;3(10-11):1467-75 - PubMed
  85. Prog Lipid Res. 2011 Apr;50(2):152-92 - PubMed
  86. Int J Immunopharmacol. 1992 Oct;14(7):1145-51 - PubMed
  87. Cell Immunol. 1985 Feb;90(2):458-63 - PubMed
  88. Nat Rev Drug Discov. 2007 Apr;6(4):313-25 - PubMed
  89. J Exp Med. 2001 Feb 19;193(4):497-507 - PubMed
  90. Int Immunol. 2008 Feb;20(2):235-45 - PubMed
  91. J Leukoc Biol. 2009 Jan;85(1):136-45 - PubMed
  92. Pharmacology. 2010;85(6):372-82 - PubMed
  93. Pharmacol Rep. 2010 May-Jun;62(3):503-10 - PubMed
  94. Trends Mol Med. 2008 Oct;14(10):461-9 - PubMed
  95. Nat Immunol. 2003 Oct;4(10):974-81 - PubMed
  96. J Clin Invest. 1987 Jun;79(6):1601-6 - PubMed
  97. Trends Immunol. 2002 Mar;23(3):144-50 - PubMed
  98. Biochem Pharmacol. 2005 Sep 1;70(5):714-24 - PubMed
  99. Am J Respir Crit Care Med. 2011 Jul 1;184(1):37-49 - PubMed
  100. J Immunol. 2011 Aug 1;187(3):1432-9 - PubMed
  101. Clin Exp Immunol. 1999 Jan;115(1):86-90 - PubMed
  102. J Immunol. 1993 Jun 15;150(12):5321-9 - PubMed
  103. J Immunol. 2002 Nov 15;169(10):5997-6004 - PubMed
  104. Pharmacol Rev. 2004 Sep;56(3):387-437 - PubMed
  105. AIDS. 2004 Apr 9;18(6):951-2 - PubMed
  106. J Biol Chem. 2007 Aug 3;282(31):22254-66 - PubMed
  107. J Biol Chem. 2006 Jul 28;281(30):21535-21545 - PubMed
  108. J Immunol. 2003 Dec 15;171(12):6389-95 - PubMed
  109. Adv Enzyme Regul. 2011;51(1):59-64 - PubMed
  110. Nature. 1977 Jan 13;265(5590):170-3 - PubMed
  111. Nat Immunol. 2003 Oct;4(10):965-73 - PubMed
  112. Immunol Lett. 2006 Feb 15;102(2):121-31 - PubMed
  113. J Immunol. 1995 Apr 15;154(8):3654-66 - PubMed
  114. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11673-8 - PubMed
  115. Clin Transplant. 2012 Jan-Feb;26(1):E38-47 - PubMed
  116. J Immunol. 2011 May 1;186(9):5119-30 - PubMed
  117. IUBMB Life. 2010 Aug;62(8):591-6 - PubMed
  118. J Immunol. 1998 Sep 15;161(6):2723-30 - PubMed
  119. J Immunol. 1979 Apr;122(4):1563-71 - PubMed
  120. Int Immunopharmacol. 2009 May;9(5):534-9 - PubMed
  121. J Leukoc Biol. 2007 Mar;81(3):809-17 - PubMed
  122. Pharmacol Rev. 2011 Sep;63(3):539-84 - PubMed
  123. Clin Exp Immunol. 2001 Jan;123(1):105-11 - PubMed
  124. Cancer Immunol Immunother. 2012 Jul;61(7):1045-53 - PubMed
  125. Cardiovasc Drugs Ther. 2009 Feb;23(1):49-59 - PubMed
  126. Cancer Res. 2007 Sep 15;67(18):8865-73 - PubMed
  127. Biochem J. 2009 Dec 23;425(2):381-8 - PubMed
  128. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:3-58 - PubMed
  129. Nat Rev Immunol. 2004 Sep;4(9):711-24 - PubMed
  130. Mol Cells. 2010 Nov;30(5):383-91 - PubMed
  131. Pharmacol Rev. 2011 Sep;63(3):471-538 - PubMed
  132. Cell. 1995 Dec 1;83(5):803-12 - PubMed
  133. Life Sci. 2001 Apr 6;68(19-20):2207-12 - PubMed
  134. J Clin Invest. 2002 Apr;109(7):883-93 - PubMed
  135. J Immunol. 1999 Jul 1;163(1):111-9 - PubMed
  136. J Exp Med. 2005 Jul 4;202(1):97-110 - PubMed
  137. Pharmacol Rev. 2003 Mar;55(1):195-227 - PubMed
  138. Biochem Pharmacol. 2010 Sep 15;80(6):838-45 - PubMed
  139. J Immunol. 2005 Aug 1;175(3):1483-90 - PubMed
  140. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):21-6 - PubMed
  141. J Immunol. 2002 Feb 1;168(3):1372-9 - PubMed
  142. J Immunol. 1988 Feb 1;140(3):936-40 - PubMed
  143. Am J Respir Cell Mol Biol. 2007 Jun;36(6):715-20 - PubMed
  144. Eur J Immunol. 1997 Dec;27(12):3526-31 - PubMed
  145. J Immunol. 1991 Jan 1;146(1):108-13 - PubMed
  146. Cancer Prev Res (Phila). 2011 Aug;4(8):1198-208 - PubMed
  147. AIDS. 2006 Apr 4;20(6):813-20 - PubMed
  148. Immunology. 2007 Jul;121(3):427-36 - PubMed
  149. Am J Reprod Immunol. 2002 May;47(5):295-302 - PubMed
  150. Am J Respir Crit Care Med. 2001 Jan;163(1):226-33 - PubMed
  151. J Immunol. 2000 Mar 1;164(5):2277-80 - PubMed
  152. J Allergy Clin Immunol. 2006 Mar;117(3):577-82 - PubMed
  153. Clin Immunol. 2005 Feb;114(2):100-9 - PubMed
  154. Biochem Biophys Res Commun. 2004 Apr 16;316(4):1009-14 - PubMed
  155. Pharmacol Rev. 2006 Sep;58(3):375-88 - PubMed
  156. Biochem J. 2004 Dec 15;384(Pt 3):469-76 - PubMed
  157. Eur J Pharmacol. 2003 Apr 25;467(1-3):151-61 - PubMed
  158. Biochem J. 2000 Feb 1;345 Pt 3:401-15 - PubMed
  159. J Exp Med. 2000 Aug 7;192(3):421-32 - PubMed
  160. Biochem Biophys Res Commun. 1999 Oct 22;264(2):321-6 - PubMed
  161. J Biol Chem. 2010 Sep 3;285(36):27571-80 - PubMed
  162. Cancer Res. 2005 Jun 15;65(12):5211-20 - PubMed
  163. J Immunol. 2005 Aug 1;175(3):1658-64 - PubMed
  164. J Leukoc Biol. 2000 Dec;68(6):881-9 - PubMed
  165. Pharmacol Ther. 2004 May;102(2):139-53 - PubMed
  166. EMBO J. 1995 Aug 1;14(15):3731-40 - PubMed
  167. J Immunol. 1998 Feb 15;160(4):1894-900 - PubMed
  168. Prostaglandins Leukot Essent Fatty Acids. 2009 Apr;80(4):195-200 - PubMed
  169. J Pharmacol Exp Ther. 2010 Mar;332(3):764-75 - PubMed
  170. J Immunol. 2008 Feb 1;180(3):1390-7 - PubMed
  171. Transplantation. 1987 Apr;43(4):472-8 - PubMed
  172. Pharmacology. 2010;85(6):336-49 - PubMed
  173. Nature. 1997 Jun 5;387(6633):620-4 - PubMed
  174. Transplantation. 1989 Oct;48(4):660-6 - PubMed
  175. Br J Pharmacol. 2002 Oct;137(3):315-22 - PubMed
  176. Life Sci. 2003 Dec 5;74(2-3):391-5 - PubMed
  177. J Immunol. 1992 May 1;148(9):2845-52 - PubMed
  178. J Exp Med. 2001 Jan 15;193(2):255-61 - PubMed
  179. Immunology. 2002 Jan;105(1):23-34 - PubMed
  180. J Immunol. 2003 Nov 15;171(10):5148-56 - PubMed
  181. J Exp Med. 1977 Dec 1;146(6):1719-34 - PubMed
  182. J Pharmacol Sci. 2010;112(1):1-5 - PubMed

Publication Types