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Ibrahim IH, Sallam SM, Omar H, et al. Oxidative hemolysis of erythrocytes induced by various vitamins. Int J Biomed Sci. 2006;2(3):295-8
Ibrahim, I. H., Sallam, S. M., Omar, H., & Rizk, M. (2006). Oxidative hemolysis of erythrocytes induced by various vitamins. International journal of biomedical science : IJBS, 2(3), 295-8.
Ibrahim, I H, et al. "Oxidative hemolysis of erythrocytes induced by various vitamins." International journal of biomedical science : IJBS vol. 2,3 (2006): 295-8.
Ibrahim IH, Sallam SM, Omar H, Rizk M. Oxidative hemolysis of erythrocytes induced by various vitamins. Int J Biomed Sci. 2006 Sep;2(3):295-8. PMID: 23674994; PMCID: PMC3614607.
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Int J Biomed Sci. 2006 Sep;2(3):295-8.

Oxidative hemolysis of erythrocytes induced by various vitamins.

International journal of biomedical science : IJBS

I H Ibrahim, S M Sallam, H Omar, M Rizk

Affiliations

  1. Department of Physics, Faculty of Science, Ain Shams University, Cairo. Egypt;

PMID: 23674994 PMCID: PMC3614607

Abstract

Hemolytic effect of some water-soluble vitamins (niacin B5, pyridoxine B6, thiamine B1 and ascorbic and acid C) on erythrocytes was studied spectrophotometrically at relatively high concentration. The oxidation mechanism of hemoglobin was the same for the used vitamins. Vitamin C was the strongest hemolytic agent in comparison with the other vitamins, while vitamin B1 is the weakest one. The results were confirmed by studying the variation in conductivity of erythrocytes with temperature in the range 20-40°C for the used vitamins at a concentration of 2 mM and after two hours from adding each vitamin to the erythrocytes suspension. The conductivity measurements show that the conductivity for the used vitamins is lower than that for control (without adding vitamin) due to hemoglobin oxidation, also may be due to the electrical reorganization of the erythrocyte membrane after the interaction of the used vitamin with it. The obtained results insure the oxidizing effect of the used vitamins on hemoglobin and consequently their hemolytic effect on erythrocytes.

Keywords: ascorbic acid; conductivity; erythrocytes; hemolysis; niacin; pyridoxine; thiamine

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