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Rajian JR, Shao X, Chamberland DL, et al. Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model. Biomed Opt Express. 2013;4(6):900-8doi: 10.1364/BOE.4.000900.
Rajian, J. R., Shao, X., Chamberland, D. L., & Wang, X. (2013). Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model. Biomedical optics express, 4(6), 900-8. https://doi.org/10.1364/BOE.4.000900
Rajian, Justin R, et al. "Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model." Biomedical optics express vol. 4,6 (2013): 900-8. doi: https://doi.org/10.1364/BOE.4.000900
Rajian JR, Shao X, Chamberland DL, Wang X. Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model. Biomed Opt Express. 2013 May 17;4(6):900-8. doi: 10.1364/BOE.4.000900. Print 2013 Jun 01. PMID: 23761851; PMCID: PMC3675868.
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Biomed Opt Express. 2013 May 17;4(6):900-8. doi: 10.1364/BOE.4.000900. Print 2013 Jun 01.

Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model.

Biomedical optics express

Justin R Rajian, Xia Shao, David L Chamberland, Xueding Wang

Affiliations

  1. Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

PMID: 23761851 PMCID: PMC3675868 DOI: 10.1364/BOE.4.000900

Abstract

Neovascularity also known as angiogenesis is an early feature of inflammatory arthritis disease. Therefore, identifying the development of neovascularity is one way to potentially detect and characterize arthritis. Laser-based photoacoustic imaging (PAI) is an emerging biomedical imaging modality which may aid in the detection of both early and continued development of neovascularity. In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment. The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints. In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints. The diameters of the ankle joints, as a clinical score of the arthritis, were also measured at each time point.

Keywords: (110.7170) Ultrasound; (170.5120) Photoacoustic imaging

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