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Masi AT, Elmore KB, Rehman AA, et al. Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels. Autoimmune Dis. 2013;2013:593493doi: 10.1155/2013/593493.
Masi, A. T., Elmore, K. B., Rehman, A. A., Chatterton, R. T., Goertzen, N. J., & Aldag, J. C. (2013). Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels. Autoimmune diseases, 2013593493. https://doi.org/10.1155/2013/593493
Masi, Alfonse T, et al. "Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels." Autoimmune diseases vol. 2013 (2013): 593493. doi: https://doi.org/10.1155/2013/593493
Masi AT, Elmore KB, Rehman AA, Chatterton RT, Goertzen NJ, Aldag JC. Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels. Autoimmune Dis. 2013;2013:593493. doi: 10.1155/2013/593493. Epub 2013 May 22. PMID: 23762532; PMCID: PMC3674651.
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Autoimmune Dis. 2013;2013:593493. doi: 10.1155/2013/593493. Epub 2013 May 22.

Lower Serum Androstenedione Levels in Pre-Rheumatoid Arthritis versus Normal Control Women: Correlations with Lower Serum Cortisol Levels.

Autoimmune diseases

Alfonse T Masi, Kevin B Elmore, Azeem A Rehman, Robert T Chatterton, Ned J Goertzen, Jean C Aldag

Affiliations

  1. Department of Medicine, University of Illinois College of Medicine (UICOMP), One Illini Drive, Peoria, IL 61656, USA.

PMID: 23762532 PMCID: PMC3674651 DOI: 10.1155/2013/593493

Abstract

Serum adrenal androgens (AAs), including androstenedione (Δ4A) and dehydroepiandrosterone sulfate (DHEAS), have been reported to be lower in female rheumatoid arthritis (RA) patients with early disease. Few data are available on hormonal status of women before the onset of clinical rheumatoid arthritis (pre-RA). A broad baseline panel of serum adrenal and sex steroids was compared in 36 female pre-RA to 144 matched cohort control (CN) subjects to determine differences in their mean values and in patterns of hormonal correlations. Study subjects having lower versus higher baseline serum cortisol levels than the total group's mean value were also analyzed separately to investigate differences in their hormonal levels and correlational patterns. In total subjects, mean (±SE) Δ4A level (nmol/L) was lower (P = 0.018) in 28 pre-RA cases (6.4 ± 0.40) versus 108 CN (7.8 ± 0.28). The significant (P = 0.013) difference was restricted to 9 pre-RA versus 53 CN subjects having lower cortisol levels (5.6 ± 0.73 versus 8.0 ± 0.42 nmol/L, resp.). In total subjects, no significant difference was found between study subjects in their bivariate correlations of the hormonal panel variables, unlike results found in the subgroups stratified by lower versus higher cortisol levels. A subgroup of pre-RA females may have relative adrenal cortical insufficiency, as reflected by lower Δ4A, especially observed among those subjects with lower cortisol levels.

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