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Kluck J, O'Flynn RM, Kaplan DE, et al. Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center. Hepat Res Treat. 2013;2013:653976doi: 10.1155/2013/653976.
Kluck, J., O'Flynn, R. M., Kaplan, D. E., & Chang, K. M. (2013). Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center. Hepatitis research and treatment, 2013653976. https://doi.org/10.1155/2013/653976
Kluck, Joseph, et al. "Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center." Hepatitis research and treatment vol. 2013 (2013): 653976. doi: https://doi.org/10.1155/2013/653976
Kluck J, O'Flynn RM, Kaplan DE, Chang KM. Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center. Hepat Res Treat. 2013;2013:653976. doi: 10.1155/2013/653976. Epub 2013 May 16. PMID: 23762548; PMCID: PMC3670541.
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Hepat Res Treat. 2013;2013:653976. doi: 10.1155/2013/653976. Epub 2013 May 16.

Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center.

Hepatitis research and treatment

Joseph Kluck, Rose M O'Flynn, David E Kaplan, Kyong-Mi Chang

Affiliations

  1. Department of Pharmacy, Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA ; Department of Pharmacy, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

PMID: 23762548 PMCID: PMC3670541 DOI: 10.1155/2013/653976

Abstract

Objectives. This study was performed to define the overall treatment response rates and treatment completion rates among the population of Hepatitis C infected patients at an urban VA Medical Center. Additionally, we examined whether pretreatment liver biopsy is a positive predictor for treatment completion and if the presence of mental health disorders is a negative predictor for treatment completion. Methods. Retrospective chart review was performed on the 375 patients that were treated for HCV and met the study inclusion parameters between January 1, 2003 and April 1, 2008 at our institution. Clinical data was obtained from the computerized patient record system and was analyzed for respective parameters. Results. Sustained virological response was achieved in 116 (31%) patients. 169 (45%) patients completed a full treatment course. Also, 44% of patients who received a pre-treatment liver biopsy completed treatment versus 46% completion rates for patients who did not receive a pretreatment liver biopsy. Baseline ICD9 diagnosis of a mental health disorder was not associated with higher treatment discontinuation rates. Conclusions. In conclusion, pretreatment liver biopsy was not a positive predictor for treatment completion, and the presence of mental health disorders was not a negative predictor for treatment completion.

References

  1. N Engl J Med. 2001 Jul 5;345(1):41-52 - PubMed
  2. N Engl J Med. 2000 Dec 7;343(23):1666-72 - PubMed
  3. Hepatology. 2006 Sep;44(3):521-6 - PubMed
  4. Clin Infect Dis. 2009 Jan 15;48(2):186-93 - PubMed
  5. N Engl J Med. 1998 Nov 19;339(21):1485-92 - PubMed
  6. Ann Intern Med. 2004 Mar 2;140(5):346-55 - PubMed
  7. Lancet. 2001 Sep 22;358(9286):958-65 - PubMed
  8. Am J Gastroenterol. 2006 Oct;101(10):2360-78 - PubMed
  9. J Clin Gastroenterol. 2004 Mar;38(3):279-84 - PubMed
  10. N Engl J Med. 2000 Dec 7;343(23):1673-80 - PubMed
  11. N Engl J Med. 2002 Sep 26;347(13):975-82 - PubMed
  12. J Clin Pharmacol. 2004 Jan;44(1):20-9 - PubMed
  13. World J Gastroenterol. 2007 May 7;13(17):2436-41 - PubMed
  14. N Engl J Med. 1998 Nov 19;339(21):1493-9 - PubMed
  15. Hepatology. 2002 Nov;36(5 Suppl 1):S237-44 - PubMed
  16. Lancet. 1997 Mar 22;349(9055):825-32 - PubMed
  17. Gastroenterology. 1997 Feb;112(2):463-72 - PubMed
  18. Am J Gastroenterol. 2000 Mar;95(3):740-7 - PubMed
  19. Schizophr Bull. 2010 Jan;36(1):165-72 - PubMed
  20. J Clin Gastroenterol. 2010 Sep;44(8):e178-85 - PubMed
  21. Brain Behav Immun. 2005 Jan;19(1):23-7 - PubMed
  22. Hepatology. 2011 Oct;54(4):1433-44 - PubMed
  23. Hepatology. 2009 Apr;49(4):1335-74 - PubMed
  24. Hepatology. 2005 Jan;41(1):88-96 - PubMed
  25. Gastroenterol Clin North Am. 2004 Mar;33(1 Suppl):S35-50 - PubMed
  26. Hepatology. 2004 Oct;40(4):892-9 - PubMed
  27. Am J Psychiatry. 2000 Jun;157(6):867-76 - PubMed
  28. Ann Intern Med. 2006 May 16;144(10):705-14 - PubMed
  29. N Engl J Med. 2006 Dec 7;355(23):2444-51 - PubMed
  30. Patient Prefer Adherence. 2012;6:285-95 - PubMed
  31. Hepatology. 2007 Jul;46(1):37-47 - PubMed
  32. Hepatology. 2002 Nov;36(5 Suppl 1):S152-60 - PubMed

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