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Vernon PJ, Zeh Iii HJ, Lotze MT. The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products. Oncoimmunology. 2013;2(5):e24184doi: 10.4161/onci.24184.
Vernon, P. J., Zeh Iii, H. J., & Lotze, M. T. (2013). The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products. Oncoimmunology, 2(5), e24184. https://doi.org/10.4161/onci.24184
Vernon, Philip J, et al. "The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products." Oncoimmunology vol. 2,5 (2013): e24184. doi: https://doi.org/10.4161/onci.24184
Vernon PJ, Zeh Iii HJ, Lotze MT. The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products. Oncoimmunology. 2013 May 01;2(5):e24184. doi: 10.4161/onci.24184. PMID: 23762800; PMCID: PMC3667906.
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Oncoimmunology. 2013 May 01;2(5):e24184. doi: 10.4161/onci.24184.

The myeloid response to pancreatic carcinogenesis is regulated by the receptor for advanced glycation end-products.

Oncoimmunology

Philip J Vernon, Herbert J Zeh Iii, Michael T Lotze

Affiliations

  1. Department of Surgery; Hillman Cancer Center; University of Pittsburgh Cancer Institute; Pittsburgh, PA USA.

PMID: 23762800 PMCID: PMC3667906 DOI: 10.4161/onci.24184

Abstract

We identified a critical role for receptor for advanced glycation end products (RAGE) in the intratumoral accumulation of myeloid-derived suppressor cells (MDSCs) during pancreatic carcinogenesis. The absence of RAGE markedly delayed neoplasia and limited MDSC accumulation in mice expressing an oncogenic variant of

Keywords: DAMPs; MDSCs; RAGE; pancreatic carcinogenesis

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