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Kasperska-Zajac A, Grzanka A, Machura E, et al. Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration. J Inflamm (Lond). 2013;10(1):22doi: 10.1186/1476-9255-10-22.
Kasperska-Zajac, A., Grzanka, A., Machura, E., Misiolek, M., Mazur, B., & Jochem, J. (2013). Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration. Journal of inflammation (London, England), 10(1), 22. https://doi.org/10.1186/1476-9255-10-22
Kasperska-Zajac, Alicja, et al. "Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration." Journal of inflammation (London, England) vol. 10,1 (2013): 22. doi: https://doi.org/10.1186/1476-9255-10-22
Kasperska-Zajac A, Grzanka A, Machura E, Misiolek M, Mazur B, Jochem J. Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration. J Inflamm (Lond). 2013 May 24;10(1):22. doi: 10.1186/1476-9255-10-22. PMID: 23706062; PMCID: PMC3680025.
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J Inflamm (Lond). 2013 May 24;10(1):22. doi: 10.1186/1476-9255-10-22.

Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration.

Journal of inflammation (London, England)

Alicja Kasperska-Zajac, Alicja Grzanka, Edyta Machura, Maciej Misiolek, Bogdan Mazur, Jerzy Jochem

Affiliations

  1. Clinical Department of Internal Diseases, Allergology and Clinical Immunology, ul, Ceglana 35, 40-952 Katowice, Poland. [email protected].

PMID: 23706062 PMCID: PMC3680025 DOI: 10.1186/1476-9255-10-22

Abstract

Chronic spontaneous urticaria (CU) is associated with activation of the acute phase response (APR). Nevertheless, APR-associated proteins have not been well characterized as potential biomarkers of the disease severity. To assess the pattern of complement proteins C3 and C4 - the acute phase reactants in patients with CU. C3, C4 and CRP concentrations were measured in serum of 70 patients showing different degrees of urticarial severity as well as in 33 healthy subjects. Serum C3 and C4 concentrations were significantly increased in CU patients as compared with the healthy subjects and exceed the normal lab range by about 5% and 10%, respectively. Significant differences were found between patients with mild and increased CU severity. In addition, significant correlations were observed between C3, C4 and CRP concentrations. More severe CU is characterized by higher production of C3 and C4 complements accompanied by parallel changes in CRP concentration.

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