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Chatterjee T, Gupta S, Sharma A, et al. Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia. Mediterr J Hematol Infect Dis. 2013;5(1):e2013042doi: 10.4084/MJHID.2013.042.
Chatterjee, T., Gupta, S., Sharma, A., Sharma, S., & Gupta, D. (2013). Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia. Mediterranean journal of hematology and infectious diseases, 5(1), e2013042. https://doi.org/10.4084/MJHID.2013.042
Chatterjee, Tathagata, et al. "Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia." Mediterranean journal of hematology and infectious diseases vol. 5,1 (2013): e2013042. doi: https://doi.org/10.4084/MJHID.2013.042
Chatterjee T, Gupta S, Sharma A, Sharma S, Gupta D. Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia. Mediterr J Hematol Infect Dis. 2013 Jun 04;5(1):e2013042. doi: 10.4084/MJHID.2013.042. Print 2013. PMID: 23795280; PMCID: PMC3684347.
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Mediterr J Hematol Infect Dis. 2013 Jun 04;5(1):e2013042. doi: 10.4084/MJHID.2013.042. Print 2013.

Acute panmyelosis with myelofibrosis - a rare subtype of acute myeloid leukemia.

Mediterranean journal of hematology and infectious diseases

Tathagata Chatterjee, Srishti Gupta, Ajay Sharma, Sanjeevan Sharma, Devika Gupta

Affiliations

  1. Department of Immunohematology and Transfusion Medicine, AFMC, Pune - 411040 India.

PMID: 23795280 PMCID: PMC3684347 DOI: 10.4084/MJHID.2013.042

Abstract

One case of acute panmyelosis with myelofibrosis (APMF) is here reported. A 45 year old male presented with abrupt onset of rapidly progressing low backache, weakness and pancytopenia. On examination there was no organomegaly. Peripheral blood examination revealed normocytic normochromic red blood cells with 10% circulating blasts. Flowcytometric examination of peripheral blood revealed blasts which were positive for CD34, HLA- DR and myeloid associated antigens (i.e. CD13 and CD33). Blasts were negative for anti MPO. Bone marrow aspirate resulted in a dry tap. Bone marrow biopsy revealed panmyeloid proliferation with scattered blasts which were CD34 positive on imunohistochemistry and negative for anti MPO. Reticulin stain showed grade III myelofibrosis (WHO). Differential diagnosis considered included AML-M7, MDS-RAEB II and AML with myelodysplasia. He was started on chemotherapy [idarubicin and cytarabine; 3+7 induction regimen followed by three cycles of HIDAC (High dose cytosine arabinoside)] after which patient was in complete morphological remission with markedly reduced bone marrow fibrosis. He is now being worked up for allogeneic stem cell transplantation. Patient is asymptomatic at eight months of diagnosis. In conclusion these patients should be managed aggressively with AML therapy and this case report reaffirms the fact that APMF is subtype of AML.

References

  1. Ann Hematol. 2004 Aug;83(8):513-21 - PubMed
  2. Leuk Res. 2001 Oct;25(10):829-38 - PubMed
  3. Br J Haematol. 1981 Sep;49(1):11-6 - PubMed
  4. Cancer Genet Cytogenet. 1996 Aug;90(1):24-8 - PubMed
  5. Leuk Lymphoma. 2004 Apr;45(4):681-7 - PubMed
  6. Mod Pathol. 2005 May;18(5):603-14 - PubMed

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