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Song YS, Fang CH, So BI, et al. Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat. Gastroenterol Res Pract. 2013;2013:342648doi: 10.1155/2013/342648.
Song, Y. S., Fang, C. H., So, B. I., Park, J. Y., Lee, Y., Shin, J. H., Jun, D. W., Kim, H., & Kim, K. S. (2013). Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat. Gastroenterology research and practice, 2013342648. https://doi.org/10.1155/2013/342648
Song, Yi-Sun, et al. "Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat." Gastroenterology research and practice vol. 2013 (2013): 342648. doi: https://doi.org/10.1155/2013/342648
Song YS, Fang CH, So BI, Park JY, Lee Y, Shin JH, Jun DW, Kim H, Kim KS. Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat. Gastroenterol Res Pract. 2013;2013:342648. doi: 10.1155/2013/342648. Epub 2013 May 12. PMID: 23737763; PMCID: PMC3666266.
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Gastroenterol Res Pract. 2013;2013:342648. doi: 10.1155/2013/342648. Epub 2013 May 12.

Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat.

Gastroenterology research and practice

Yi-Sun Song, Cheng-Hu Fang, Byung-Im So, Jun-Young Park, Yonggu Lee, Jeong Hun Shin, Dae Won Jun, Hyuck Kim, Kyung-Soo Kim

Affiliations

  1. Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 133-792, Republic of Korea.

PMID: 23737763 PMCID: PMC3666266 DOI: 10.1155/2013/342648

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome. In this study, we investigated histological and biochemical changes in NAFLD and the gene expression involving de novo lipogenesis in Otsuka Long-Evans Tokushima fatty (OLETF) rats. We used OLETF rats and Long-Evans Tokushima Otsuka (LETO) rats as animal models of NAFLD and as controls, respectively. Consistent observations were made at 4-week intervals up to 50 weeks of age, and all rats were fed ad libitum with standard food. Biochemical and histological changes were observed, and gene expression involved in de novo lipogenesis was measured using real-time polymerase chain reactions. As a results hepatic micro- and macrovesicular steatosis and hepatocyte ballooning were evident in the OLETF rats at 22-38 weeks of age but disappeared after 42 weeks; no fibrosis or collagen deposition was observed. Gene expression involved in de novo lipogenesis followed a pattern similar to that of the histological changes. In conclusion, in the absence of dietary manipulation, hepatic steatosis in OLETF rats is evident at 22-38 weeks and declines after 42 weeks. Therefore, OLETF rats at 22-38 weeks are recommended as animal models of hepatic steatosis.

References

  1. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G619-26 - PubMed
  2. J Med Invest. 1999 Aug;46(3-4):121-9 - PubMed
  3. Mamm Genome. 1998 Jun;9(6):419-25 - PubMed
  4. N Engl J Med. 2002 Apr 18;346(16):1221-31 - PubMed
  5. Hepatology. 2006 Sep;44(3):581-91 - PubMed
  6. Diabetes. 1992 Nov;41(11):1422-8 - PubMed
  7. Gene. 1997 Sep 15;197(1-2):169-75 - PubMed
  8. Curr Opin Lipidol. 2008 Jun;19(3):295-300 - PubMed
  9. Carcinogenesis. 2007 Oct;28(10):2193-8 - PubMed
  10. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  11. Clin Genet. 2009 Jul;76(1):46-53 - PubMed
  12. Biochim Biophys Acta. 2010 Dec;1801(12):1349-60 - PubMed
  13. J Nutr Metab. 2012;2012:268680 - PubMed
  14. J Diabetes Complications. 2008 Jan-Feb;22(1):46-55 - PubMed
  15. Prog Lipid Res. 2009 Jan;48(1):1-26 - PubMed
  16. PLoS One. 2011 Feb 23;6(2):e17057 - PubMed
  17. Hepatology. 2008 Jul;48(1):109-18 - PubMed
  18. Nat Med. 2007 Oct;13(10):1193-202 - PubMed
  19. Dig Dis Sci. 1997 May;42(5):915-9 - PubMed
  20. Exp Diabetes Res. 2012;2012:762565 - PubMed
  21. Free Radic Biol Med. 2010 Feb 15;48(4):567-78 - PubMed
  22. Gastroenterology. 1998 Apr;114(4):842-5 - PubMed
  23. Br J Nutr. 2006 Feb;95(2):273-81 - PubMed
  24. Diabetes. 2001 Aug;50(8):1844-50 - PubMed
  25. Hepatology. 2004 Dec;40(6):1387-95 - PubMed
  26. PLoS Biol. 2010 Jun 29;8(6):e1000412 - PubMed
  27. Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1211-8 - PubMed
  28. Physiol Behav. 1999 Jul;66(5):869-72 - PubMed
  29. J Gastroenterol Hepatol. 2008 Jan;23(1):102-9 - PubMed
  30. Eur J Pharmacol. 2008 Jul 7;588(2-3):316-24 - PubMed
  31. Hypertension. 2005 May;45(5):1012-8 - PubMed
  32. J Korean Med Sci. 2007 Dec;22(6):1034-41 - PubMed
  33. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):258-64 - PubMed
  34. J Physiol. 2008 Sep 1;586(17):4241-9 - PubMed
  35. Liver Int. 2012 Nov;32(10):1565-73 - PubMed
  36. Biochem Biophys Res Commun. 2010 Mar 26;394(1):70-4 - PubMed
  37. J Hepatol. 2010 May;52(5):727-36 - PubMed
  38. Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:71-3 - PubMed
  39. J Gastroenterol Hepatol. 2004 Jul;19(7):799-804 - PubMed

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