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Patel HB, Mody SK, Patel HB, et al. Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN Vet Sci. 2011;2011:584342doi: 10.5402/2011/584342.
Patel, H. B., Mody, S. K., Patel, H. B., Patel, V. A., & Patel, U. D. (2011). Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN veterinary science, 2011584342. https://doi.org/10.5402/2011/584342
Patel, Harshad B, et al. "Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats." ISRN veterinary science vol. 2011 (2011): 584342. doi: https://doi.org/10.5402/2011/584342
Patel HB, Mody SK, Patel HB, Patel VA, Patel UD. Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats. ISRN Vet Sci. 2011 Dec 29;2011:584342. doi: 10.5402/2011/584342. Print 2011. PMID: 23738101; PMCID: PMC3658699.
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ISRN Vet Sci. 2011 Dec 29;2011:584342. doi: 10.5402/2011/584342. Print 2011.

Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats.

ISRN veterinary science

Harshad B Patel, Shailesh K Mody, Hitesh B Patel, Vipul A Patel, Urvesh D Patel

Affiliations

  1. Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362 001, Gujarat State, India.

PMID: 23738101 PMCID: PMC3658699 DOI: 10.5402/2011/584342

Abstract

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats. Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC). After i.v. administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution. Drug elimination was relatively faster with a total body clearance of 0.59 ± 0.03 L/h/kg. Following i.m. injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 98.20 ± 3.96 per cent. The maximum plasma drug concentration (Cmax) of 1.21 ± 0.04 μg/mL was attained at 1 h (Tmax). The drug was widely distributed as reflected by high apparent volume of distribution. The elimination half-life (t 1/2β ) of the drug was 6.26 ± 0.08  h. Following s.c. administration, the drug was rapidly absorbed (Cmax: 1.16 ± 0.02 μg/mL; tmax: 1 h) and slowly eliminated from the body. The elimination half-life and total body clearance (ClB) were 5.61 ± 0.10 h and 0.60 ± 0.03 L/h/kg, respectively. The bioavailability of moxifloxacin following s.c. administration was 90.44 ± 3.96 per cent.

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