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Rege SD, Geetha T, Pondugula SR, et al. Noncoding RNAs in Neurodegenerative Diseases. ISRN Neurol. 2013;2013:375852doi: 10.1155/2013/375852.
Rege, S. D., Geetha, T., Pondugula, S. R., Zizza, C. A., Wernette, C. M., & Babu, J. R. (2013). Noncoding RNAs in Neurodegenerative Diseases. ISRN neurology, 2013375852. https://doi.org/10.1155/2013/375852
Rege, Shraddha D, et al. "Noncoding RNAs in Neurodegenerative Diseases." ISRN neurology vol. 2013 (2013): 375852. doi: https://doi.org/10.1155/2013/375852
Rege SD, Geetha T, Pondugula SR, Zizza CA, Wernette CM, Babu JR. Noncoding RNAs in Neurodegenerative Diseases. ISRN Neurol. 2013 Apr 30;2013:375852. doi: 10.1155/2013/375852. Print 2013. PMID: 23738143; PMCID: PMC3657400.
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ISRN Neurol. 2013 Apr 30;2013:375852. doi: 10.1155/2013/375852. Print 2013.

Noncoding RNAs in Neurodegenerative Diseases.

ISRN neurology

Shraddha D Rege, Thangiah Geetha, Satyanarayana R Pondugula, Claire A Zizza, Catherine M Wernette, Jeganathan Ramesh Babu

Affiliations

  1. Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.

PMID: 23738143 PMCID: PMC3657400 DOI: 10.1155/2013/375852

Abstract

Noncoding RNAs are widely known for their various essential roles in the development of central nervous system. It involves neurogenesis, neural stem cells generation, maintenance and maturation, neurotransmission, neural network plasticity, formation of synapses, and even brain aging and DNA damage responses. In this review, we will discuss the biogenesis of microRNA, various functions of noncoding RNA's specifically microRNAs (miRNAs) that act as the chief regulators of gene expression, and focus in particular on misregulation of miRNAs which leads to several neurodegenerative diseases as well as its therapeutic outcome. Recent evidences has shown that miRNAs expression levels are changed in patients with neurodegenerative diseases; hence, miRNA can be used as a potential diagnostic biomarker and serve as an effective therapeutic tool in overcoming various neurodegenerative disease processes.

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