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Giuliani N, Lisignoli G, Magnani M, et al. New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem Cells Int. 2013;2013:312501doi: 10.1155/2013/312501.
Giuliani, N., Lisignoli, G., Magnani, M., Racano, C., Bolzoni, M., Dalla Palma, B., Spolzino, A., Manferdini, C., Abati, C., Toscani, D., Facchini, A., & Aversa, F. (2013). New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem cells international, 2013312501. https://doi.org/10.1155/2013/312501
Giuliani, Nicola, et al. "New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics." Stem cells international vol. 2013 (2013): 312501. doi: https://doi.org/10.1155/2013/312501
Giuliani N, Lisignoli G, Magnani M, Racano C, Bolzoni M, Dalla Palma B, Spolzino A, Manferdini C, Abati C, Toscani D, Facchini A, Aversa F. New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem Cells Int. 2013;2013:312501. doi: 10.1155/2013/312501. Epub 2013 May 23. PMID: 23766767; PMCID: PMC3676919.
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Stem Cells Int. 2013;2013:312501. doi: 10.1155/2013/312501. Epub 2013 May 23.

New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics.

Stem cells international

Nicola Giuliani, Gina Lisignoli, Marina Magnani, Costantina Racano, Marina Bolzoni, Benedetta Dalla Palma, Angelica Spolzino, Cristina Manferdini, Caterina Abati, Denise Toscani, Andrea Facchini, Franco Aversa

Affiliations

  1. Hematology, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43126 Parma, Italy.

PMID: 23766767 PMCID: PMC3676919 DOI: 10.1155/2013/312501

Abstract

Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors. Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one. hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration. In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.

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