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Nagpal DK, Prabhu PR, Shah A, et al. Leimyosarcoma of the buccal mucosa and review of literature. J Oral Maxillofac Pathol. 2013;17(1):149doi: 10.4103/0973-029X.110732.
Nagpal, D. K., Prabhu, P. R., Shah, A., & Palaskar, S. (2013). Leimyosarcoma of the buccal mucosa and review of literature. Journal of oral and maxillofacial pathology : JOMFP, 17(1), 149. https://doi.org/10.4103/0973-029X.110732
Nagpal, Deepak Kumar J, et al. "Leimyosarcoma of the buccal mucosa and review of literature." Journal of oral and maxillofacial pathology : JOMFP vol. 17,1 (2013): 149. doi: https://doi.org/10.4103/0973-029X.110732
Nagpal DK, Prabhu PR, Shah A, Palaskar S. Leimyosarcoma of the buccal mucosa and review of literature. J Oral Maxillofac Pathol. 2013 Jan;17(1):149. doi: 10.4103/0973-029X.110732. PMID: 23798856; PMCID: PMC3687178.
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J Oral Maxillofac Pathol. 2013 Jan;17(1):149. doi: 10.4103/0973-029X.110732.

Leimyosarcoma of the buccal mucosa and review of literature.

Journal of oral and maxillofacial pathology : JOMFP

Deepak Kumar J Nagpal, Prashant R Prabhu, Amisha Shah, Sangeeta Palaskar

Affiliations

  1. Department of Oral and Maxillofacial Pathology, Sinhgad Dental College and Hospital, Maharashtra, India.

PMID: 23798856 PMCID: PMC3687178 DOI: 10.4103/0973-029X.110732

Abstract

UNLABELLED: Leiomyosarcoma (LMS) is an uncommon malignant spindle cell tumor of the head and neck region. The occurrence is particularly rare in the buccal mucosa of the oral cavity. It is a rapidly growing tumor with aggressive behavior and poor prognosis.

METHOD: This article presents a rare case of primary leimyosarcoma of the buccal mucosa in a 35 year old female and retrospective analysis of primary oral LMS published in the English literature since past 20 years is done. Diagnosis was confirmed by immunohistochemistry profile showing positivity for vimentin, smooth muscle actin (SMA), high proliferative index displayed by Ki-67, focal positivity for pan-CK and negativity for S-100.

CONCLUSION: Based on the presence of malignant spindle cells showing positivity for vimentin and SMA, a diagnosis of leiomyosarcoma was made.

Keywords: Ki-67; leiomyosarcoma; smooth muscle actin; spindle cell

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