Display options
Cite
Nipanikar SU, Saluja M, Kuber VV, et al. An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee. J Ayurveda Integr Med. 2013;4(1):33-9doi: 10.4103/0975-9476.109549.
Nipanikar, S. U., Saluja, M., Kuber, V. V., Kadbhane, K. P., Chopra, A., & Khade, N. R. (2013). An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee. Journal of Ayurveda and integrative medicine, 4(1), 33-9. https://doi.org/10.4103/0975-9476.109549
Nipanikar, Sanjay U, et al. "An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee." Journal of Ayurveda and integrative medicine vol. 4,1 (2013): 33-9. doi: https://doi.org/10.4103/0975-9476.109549
Nipanikar SU, Saluja M, Kuber VV, Kadbhane KP, Chopra A, Khade NR. An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee. J Ayurveda Integr Med. 2013 Jan;4(1):33-9. doi: 10.4103/0975-9476.109549. PMID: 23741160; PMCID: PMC3667431.
Copy Download .nbib Format: NLM
Share it on

J Ayurveda Integr Med. 2013 Jan;4(1):33-9. doi: 10.4103/0975-9476.109549.

An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee.

Journal of Ayurveda and integrative medicine

Sanjay U Nipanikar, Manjit Saluja, Vinod V Kuber, Kalyan P Kadbhane, Arvind Chopra, Namdev R Khade

Affiliations

  1. Department of Medical Services, R and D Center, Tulip Lab Pvt. Ltd., Ranjangaon, Shirur, Pune, India.

PMID: 23741160 PMCID: PMC3667431 DOI: 10.4103/0975-9476.109549

Abstract

BACKGROUND: Currently, though pharmacological, mechanical, and surgical interventions are used, there is no known cure for osteoarthritis (OA).

OBJECTIVES: The main aim of the study was to assess the efficacy and safety of "TLPL/AY/03/2008", a polyherbal formulation on knee joint pain assessed on visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

MATERIALS AND METHODS: It was an open label, single center, prospective, clinical study conducted in 36 patients of OA Knee. Two capsules of 'TLPL/AY/03/2008' were given to all patients twice daily orally after meals for 180 days.

RESULTS: Data describing quantitative measures are expressed as mean ± SD. Comparison of variables representing categorical data was performed using Chi-square test. The mean joint pain (as assessed on VAS) reduced significantly (59.85%; P < 0.05) and the mean WOMAC combined score, WOMAC pain sub-score, WOMAC stiffness sub-score, and WOMAC difficulty sub-score also reduced significantly at the end of the study. The mean time taken by the patients to walk 50 feet too, was reduced significantly (25.26%) at the end of the study. At the end of 4 months of the treatment, no patient needed paracetamol as rescue medicine to control pain. Most of the patients had shown good overall improvement assessed by the physician and by the patients. Majority of the patients showed excellent tolerability to the study drug. No significant change in most of the safety laboratory parameters was observed at the end of the study.

CONCLUSION: The study provides good evidence in support of the efficacy and safety of the 'TLPL/AY/03/2008' in OA of knee.

Keywords: Efficacy; WOMAC osteoarthritis index; knee joint pain; osteoarthritis; polyherbal; quality of life; visual analogue scale

References

  1. J Ethnopharmacol. 2003 Aug;87(2-3):199-206 - PubMed
  2. J Biosci. 2007 Mar;32(2):299-307 - PubMed
  3. Osteoarthritis Cartilage. 2007 Apr;15(4):386-95 - PubMed
  4. Planta Med. 2006 Oct;72(12):1100-16 - PubMed
  5. Arthritis Rheum. 1995 Nov;38(11):1535-40 - PubMed
  6. Chem Biodivers. 2004 Nov;1(11):1842-53 - PubMed
  7. Arthritis Rheum. 1995 Nov;38(11):1541-6 - PubMed
  8. J Ethnopharmacol. 2006 Sep 19;107(2):249-53 - PubMed
  9. Phytother Res. 2007 Oct;21(10):905-13 - PubMed
  10. J Ethnopharmacol. 1987 Mar-Apr;19(2):193-200 - PubMed
  11. Ann Intern Med. 2000 Oct 17;133(8):635-46 - PubMed
  12. Altern Ther Health Med. 2003 May-Jun;9(3):74-9 - PubMed
  13. J Assoc Physicians India. 2005 Jul;53:634-41 - PubMed
  14. Arzneimittelforschung. 1977 Jul;27(7):1455-7 - PubMed
  15. Arthritis Res Ther. 2012 Mar 14;14(2):R63 - PubMed
  16. Thromb Res. 2003;111(4-5):259-65 - PubMed
  17. J Ethnopharmacol. 2008 Feb 28;116(1):198-203 - PubMed
  18. Phytother Res. 2006 Sep;20(9):764-72 - PubMed
  19. J Clin Rheumatol. 2004 Oct;10(5):236-45 - PubMed
  20. Arthritis Rheum. 2004 Feb;50(2):341-4 - PubMed
  21. Arthritis Rheum. 1986 Aug;29(8):1039-49 - PubMed
  22. Ann Intern Med. 2000 Nov 7;133(9):726-37 - PubMed
  23. Arthritis Rheum. 1999 Mar;42(3):397-405 - PubMed
  24. J Rheumatol. 2000 Jun;27(6):1365-72 - PubMed
  25. J Ethnopharmacol. 1997 Apr;56(2):153-8 - PubMed
  26. Fundam Clin Pharmacol. 2007 Apr;21(2):157-64 - PubMed
  27. Rheumatology (Oxford). 2006 Jan;45(1):50-2 - PubMed
  28. J Ethnopharmacol. 1994 Mar;42(1):31-7 - PubMed
  29. Int Immunopharmacol. 2006 Feb;6(2):122-32 - PubMed
  30. J Ethnopharmacol. 2006 Feb 20;103(3):478-80 - PubMed
  31. Vascul Pharmacol. 2006 Jun;44(6):406-10 - PubMed
  32. J Ethnopharmacol. 1984 Aug;11(3):319-30 - PubMed

Publication Types