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Scholl FG, Boucek MM, Chan KC, et al. Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease. World J Pediatr Congenit Heart Surg. 2010;1(1):132-6doi: 10.1177/2150135110362092.
Scholl, F. G., Boucek, M. M., Chan, K. C., Valdes-Cruz, L., & Perryman, R. (2010). Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease. World journal for pediatric & congenital heart surgery, 1(1), 132-6. https://doi.org/10.1177/2150135110362092
Scholl, Frank G, et al. "Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease." World journal for pediatric & congenital heart surgery vol. 1,1 (2010): 132-6. doi: https://doi.org/10.1177/2150135110362092
Scholl FG, Boucek MM, Chan KC, Valdes-Cruz L, Perryman R. Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease. World J Pediatr Congenit Heart Surg. 2010 Apr;1(1):132-6. doi: 10.1177/2150135110362092. PMID: 23804734.
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World J Pediatr Congenit Heart Surg. 2010 Apr;1(1):132-6. doi: 10.1177/2150135110362092.

Preliminary experience with cardiac reconstruction using decellularized porcine extracellular matrix scaffold: human applications in congenital heart disease.

World journal for pediatric & congenital heart surgery

Frank G Scholl, Mark M Boucek, Kak-Chen Chan, Lilliam Valdes-Cruz, Richard Perryman

Affiliations

  1. The Cardiac Center, Joe DiMaggio Children's Hospital, Hollywood, FL, USA.

PMID: 23804734 DOI: 10.1177/2150135110362092

Abstract

An ideal material for repair of congenitally malformed hearts would encourage tissue regeneration with growth potential. Decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) promotes tissue regeneration in animal models and noncardiac human applications. This retrospective review evaluates SIS-ECM for reconstruction of congenital heart defects. From June 2007 to May 2009, SIS-ECM patches were used in 43 operations on 40 patients aged 2 days to 13 years. In 16 cases, the SIS-ECM was used for pericardial closure. The SIS-ECM was used for cardiac or great vessel repair in 37 cases: atrial septal defect repair in 11, pulmonary arterioplasty in 10, right ventricular outflow tract patch in 6, pulmonary monocusp valve creation in 5, superior vena cava patch in 2 and aortoplasty in 2, valve leaflet augmentation in 2, and repair of unroofed coronary sinus in 1. Follow-up was complete. There were 5 deaths, all unrelated to the SIS-ECM. Mean follow-up was 7.85 months (0.5-24 months). No pericardial effusions or intracardiac or intravascular thromboses occurred related to the SIS-ECM. The patches did not shrink or calcify. Four of 5 monocusp valves were competent and none were stenotic. One patient who underwent tricuspid valve anterior leaflet augmentation with SIS-ECM required tricuspid valve replacement 4 months later for severe regurgitation following a catheter-based procedure. Explanted tissue showed resorption of the SIS-ECM, replacement with organized collagen, and re-endothelialization. Repair of congenital heart defects using SIS-ECM is feasible and safe. In valve reconstruction, this procedure shows potential for replacement by autologous tissue. Longer-term follow-up is required to assess the potential for growth.

Keywords: congenital heart defects; congenital heart disease; congenital heart surgery; extracellular matrix; stem cells; tissue engineering

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