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Seddon JA, Perez-Velez CM, Schaaf HS, et al. Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children. J Pediatric Infect Dis Soc. 2013;2(2):100-9doi: 10.1093/jpids/pit012.
Seddon, J. A., Perez-Velez, C. M., Schaaf, H. S., Furin, J. J., Marais, B. J., Tebruegge, M., Detjen, A., Hesseling, A. C., Shah, S., Adams, L. V., Starke, J. R., Swaminathan, S., Becerra, M. C. (2013). Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children. Journal of the Pediatric Infectious Diseases Society, 2(2), 100-9. https://doi.org/10.1093/jpids/pit012
Seddon, James A, et al. "Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children." Journal of the Pediatric Infectious Diseases Society vol. 2,2 (2013): 100-9. doi: https://doi.org/10.1093/jpids/pit012
Seddon JA, Perez-Velez CM, Schaaf HS, Furin JJ, Marais BJ, Tebruegge M, Detjen A, Hesseling AC, Shah S, Adams LV, Starke JR, Swaminathan S, Becerra MC. Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children. J Pediatric Infect Dis Soc. 2013 Jun;2(2):100-9. doi: 10.1093/jpids/pit012. Epub 2013 Apr 10. PMID: 23717785; PMCID: PMC3665326.
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J Pediatric Infect Dis Soc. 2013 Jun;2(2):100-9. doi: 10.1093/jpids/pit012. Epub 2013 Apr 10.

Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children.

Journal of the Pediatric Infectious Diseases Society

James A Seddon, Carlos M Perez-Velez, H Simon Schaaf, Jennifer J Furin, Ben J Marais, Marc Tebruegge, Anne Detjen, Anneke C Hesseling, Sarita Shah, Lisa V Adams, Jeffrey R Starke, Soumya Swaminathan, Mercedes C Becerra,

Affiliations

  1. Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.
  2. Grupo Tuberculosis Valle-Colorado, and Clínica León XIII IPS Universidad de Antioquia, Medellín, Antioquia, Colombia.
  3. Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Tygerberg Children's Hospital, Cape Town, South Africa.
  4. Division of Infectious Diseases, TB Research Unit, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  5. Sydney Institute for Emerging Infectious Diseases and Biosecurity, and The Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Australia.
  6. Academic Unit of Clinical and Experimental Science, Faculty of Medicine, and Institute for Life Sciences, University of Southampton, United Kingdom Department of Paediatrics, Faculty of Medicine, University of Melbourne, Australia.
  7. The International Union Against Tuberculosis and Lung Disease, New York, and.
  8. Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  9. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
  10. Section of Infectious Disease and International Health, Global Health Initiative, Dartmouth Medical School, Hanover, New Hampshire.
  11. Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
  12. National Institute for Research in Tuberculosis, Chennai, India.
  13. Department of Global Health and Social Medicine, Harvard Medical School Partners In Health, Boston, Massachusetts.

PMID: 23717785 PMCID: PMC3665326 DOI: 10.1093/jpids/pit012

Abstract

Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome.

© The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society.

Keywords: Children; Consensus; Definition; Drug-Resistance; Pediatric; Tuberculosis

References

  1. Lancet. 2005 Jan 8-14;365(9454):130-4 - PubMed
  2. Pediatr Radiol. 2004 Nov;34(11):886-94 - PubMed
  3. Int J Tuberc Lung Dis. 2012 Aug;16(8):1033-9 - PubMed
  4. J Immunol. 2010 Jul 1;185(1):15-22 - PubMed
  5. Int J Tuberc Lung Dis. 2012 Feb;16(2):157-62 - PubMed
  6. Antimicrob Agents Chemother. 2006 Aug;50(8):2640-9 - PubMed
  7. PLoS Med. 2009 Feb 10;6(2):e2 - PubMed
  8. Am J Public Health. 2009 Aug;99(8):1486-90 - PubMed
  9. Chest. 2005 Sep;128(3):1406-13 - PubMed
  10. Trop Med Int Health. 2009 Oct;14(10):1173-89 - PubMed
  11. Int J Tuberc Lung Dis. 2010 Mar;14(3):275-81 - PubMed
  12. Infect Dis Clin North Am. 2010 Sep;24(3):727-49 - PubMed
  13. Int J Tuberc Lung Dis. 2012 Feb;16(2):196-202 - PubMed
  14. Int J Tuberc Lung Dis. 2005 Jun;9(6):640-5 - PubMed
  15. Pediatrics. 2006 Jun;117(6):2022-9 - PubMed
  16. Tuberculosis (Edinb). 2003;83(1-3):208-12 - PubMed
  17. Am J Hyg. 1952 Sep;56(2):139-214 - PubMed
  18. Tubercle. 1961 Mar;42(Suppl):1-40 - PubMed
  19. Lancet Infect Dis. 2012 Jun;12(6):449-56 - PubMed
  20. Bull World Health Organ. 2014 Sep 1;92(9):672-9 - PubMed
  21. Int J Tuberc Lung Dis. 2004 Apr;8(4):392-402 - PubMed
  22. AIDS. 2010 Aug 24;24(13):2009-17 - PubMed
  23. Clin Infect Dis. 2006 Apr 15;42(8):e69-71 - PubMed
  24. Int J Tuberc Lung Dis. 2011 Mar;15(3):344-51 - PubMed
  25. N Engl J Med. 2012 Jul 26;367(4):348-61 - PubMed
  26. Am J Respir Crit Care Med. 2006 May 15;173(10):1078-90 - PubMed
  27. CMAJ. 2002 Jul 23;167(2):131-6 - PubMed
  28. Int J Tuberc Lung Dis. 2006 Mar;10(3):259-63 - PubMed
  29. J Infect Dis. 2012 May 15;205 Suppl 2:S199-208 - PubMed
  30. Bibl Tuberc. 1970;26:28-106 - PubMed
  31. Arch Dis Child. 2005 Nov;90(11):1171-4 - PubMed
  32. BMC Pediatr. 2008 Jan 11;8:1 - PubMed
  33. Lancet Infect Dis. 2010 Nov;10(11):803-12 - PubMed
  34. Int J Tuberc Lung Dis. 2007 Apr;11(4):417-23 - PubMed
  35. Arch Dis Child. 1999 May;80(5):433-7 - PubMed
  36. Int J Tuberc Lung Dis. 2004 Mar;8(3):286-98 - PubMed
  37. Pediatr Infect Dis J. 2012 Apr;31(4):347-52 - PubMed
  38. Int J Tuberc Lung Dis. 2006 Nov;10(11):1205-11 - PubMed
  39. S Afr Med J. 2005 Aug;95(8):602-6 - PubMed
  40. Clin Infect Dis. 2012 Jan 15;54(2):157-66 - PubMed

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