Display options
Cite
Chopra S, Cherian D, Verghese PP, et al. Physiology and clinical significance of natriuretic hormones. Indian J Endocrinol Metab. 2013;17(1):83-90doi: 10.4103/2230-8210.107869.
Chopra, S., Cherian, D., Verghese, P. P., & Jacob, J. J. (2013). Physiology and clinical significance of natriuretic hormones. Indian journal of endocrinology and metabolism, 17(1), 83-90. https://doi.org/10.4103/2230-8210.107869
Chopra, Sandeep, et al. "Physiology and clinical significance of natriuretic hormones." Indian journal of endocrinology and metabolism vol. 17,1 (2013): 83-90. doi: https://doi.org/10.4103/2230-8210.107869
Chopra S, Cherian D, Verghese PP, Jacob JJ. Physiology and clinical significance of natriuretic hormones. Indian J Endocrinol Metab. 2013 Jan;17(1):83-90. doi: 10.4103/2230-8210.107869. PMID: 23776857; PMCID: PMC3659912.
Copy Download .nbib Format: NLM
Share it on

Indian J Endocrinol Metab. 2013 Jan;17(1):83-90. doi: 10.4103/2230-8210.107869.

Physiology and clinical significance of natriuretic hormones.

Indian journal of endocrinology and metabolism

Sandeep Chopra, Davis Cherian, Prashant Paul Verghese, Jubbin J Jacob

Affiliations

  1. Department of Cardiology, Christian Medical College, Ludhiana, India.

PMID: 23776857 PMCID: PMC3659912 DOI: 10.4103/2230-8210.107869

Abstract

The natriuretic system consists of the atrial natriuretic peptide (ANP) and four other similar peptides including the wrongly named brain natriuretic peptide (BNP). Chemically they are small peptide hormones predominantly secreted by the cardiac myocytes in response to stretching forces. The peptide hormones have multiple renal, hemodynamic, and antiproliferative effects through three different kinds of natriuretic receptors. Clinical interest in these peptide hormones was initially stimulated by the use of these peptides as markers to differentiate cardiac versus noncardiac causes of breathlessness. Subsequently work has been done on using these peptides to prognosticate patients with acute and chronic heart failure and those with acute myocardial infraction. Synthetic forms of both atrial- and brain-natriuretic peptides have been studied and approved for use in acute heart failure with mixed results. This review focuses on the biochemistry and physiology of this fascinating hormone system and the clinical application of these hormones.

Keywords: Atrial natriuretic peptide; brain natriuretic peptide; heart failure; natriuretic peptides

References

  1. J Clin Invest. 1990 Nov;86(5):1690-7 - PubMed
  2. Clin Chim Acta. 2008 May;391(1-2):74-9 - PubMed
  3. Int J Cardiol. 2010 Apr 1;140(1):88-94 - PubMed
  4. Hypertension. 1994 Jan;23(1):38-43 - PubMed
  5. Circulation. 2007 Jun 19;115(24):3103-10 - PubMed
  6. N Engl J Med. 2002 Jul 18;347(3):161-7 - PubMed
  7. Am J Cardiol. 2007 May 15;99(10):1429-33 - PubMed
  8. JAMA. 1998 Dec 16;280(23):1983-4 - PubMed
  9. Metabolism. 1992 Dec;41(12):1273-5 - PubMed
  10. J Hypertens. 1992 Oct;10(10):1111-4 - PubMed
  11. Endocrinology. 1992 Jan;130(1):229-39 - PubMed
  12. J Am Coll Cardiol. 2002 Jan 16;39(2):202-9 - PubMed
  13. Am J Kidney Dis. 1998 Apr;31(4):674-80 - PubMed
  14. Hypertension. 2000 Jan;35(1 Pt 1):19-24 - PubMed
  15. Hypertension. 1996 Dec;28(6):988-94 - PubMed
  16. Congest Heart Fail. 2008 Jul-Aug;14(4 Suppl 1):30-4 - PubMed
  17. Biochem Biophys Res Commun. 1994 Feb 15;198(3):1177-82 - PubMed
  18. Crit Pathw Cardiol. 2004 Dec;3(4):171-6 - PubMed
  19. Gut. 2003 Oct;52(10):1511-7 - PubMed
  20. Ital Heart J Suppl. 2004 Jan;5(1):29-35 - PubMed
  21. Am J Physiol. 1993 Mar;264(3 Pt 2):R533-8 - PubMed
  22. Biochem Biophys Res Commun. 1997 Oct 29;239(3):889-94 - PubMed
  23. Klin Wochenschr. 1988 Sep 1;66(17):752-9 - PubMed
  24. Am J Cardiol. 2003 Nov 1;92(9):1124-7 - PubMed
  25. Biochem Biophys Res Commun. 1994 Aug 30;203(1):602-7 - PubMed
  26. Anadolu Kardiyol Derg. 2008 Jun;8(3):188-91 - PubMed
  27. Heart. 2005 Dec;91(12):1573-7 - PubMed
  28. Endocr Res. 2007;32(1-2):1-8 - PubMed
  29. Int J Cardiol. 2007 Apr 12;117(1):75-9 - PubMed
  30. Circulation. 1987 Jul;76(1):115-24 - PubMed
  31. J Am Coll Cardiol. 1999 Jul;34(1):155-62 - PubMed
  32. Scand J Clin Lab Invest. 1993 Feb;53(1):41-9 - PubMed
  33. Circulation. 2003 Apr 15;107(14):1884-90 - PubMed
  34. Circulation. 1992 Oct;86(4):1081-8 - PubMed
  35. J Clin Endocrinol Metab. 1996 Dec;81(12):4324-8 - PubMed
  36. Clin Sci (Lond). 1999 Feb;96(2):129-36 - PubMed
  37. Acad Emerg Med. 2003 Mar;10(3):198-204 - PubMed
  38. J Intern Med. 1994 Jun;235(6):561-76 - PubMed
  39. Curr Neurovasc Res. 2007 Aug;4(3):170-5 - PubMed
  40. Ann Card Anaesth. 2010 May-Aug;13(2):123-9 - PubMed
  41. Crit Care Med. 2004 Mar;32(3):660-5 - PubMed
  42. Trends Endocrinol Metab. 2003 Nov;14(9):411-6 - PubMed
  43. Heart Fail Rev. 2000 Jun;5(2):167-73 - PubMed
  44. Genomics. 1990 Oct;8(2):304-12 - PubMed
  45. Am J Physiol. 1984 Nov;247(5 Pt 2):F863-6 - PubMed
  46. J Biol Chem. 1995 Mar 3;270(9):4668-74 - PubMed
  47. J Am Coll Cardiol. 2001 Jun 1;37(7):1820-6 - PubMed
  48. Diab Vasc Dis Res. 2008 Mar;5(1):19-24 - PubMed
  49. Lancet. 1997 Jan 25;349(9047):245-9 - PubMed
  50. Chest. 2004 Oct;126(4):1330-6 - PubMed
  51. Fetal Diagn Ther. 2002 Jan-Feb;17(1):37-41 - PubMed
  52. J Clin Endocrinol Metab. 1996 Nov;81(11):3871-6 - PubMed
  53. Nature. 1988 Mar 3;332(6159):78-81 - PubMed
  54. N Engl J Med. 1994 Nov 24;331(21):1449-50 - PubMed
  55. Circulation. 2003 May 20;107(19):2440-5 - PubMed
  56. Blood Press Suppl. 1994;5:49-53 - PubMed
  57. Life Sci. 1981 Jan 5;28(1):89-94 - PubMed
  58. Biochem Biophys Res Commun. 1989 Jan 16;158(1):120-8 - PubMed
  59. Circulation. 1991 Oct;84(4):1581-8 - PubMed
  60. Circulation. 2004 Oct 12;110(15):2168-74 - PubMed
  61. Int J Cardiol. 1989 Oct;25(1):141-3 - PubMed
  62. J Am Coll Cardiol. 2005 Jun 7;45(11):1900-2 - PubMed
  63. J Heart Valve Dis. 2005 Nov;14(6):735-41 - PubMed
  64. Biochem J. 1987 Apr 1;243(1):183-7 - PubMed
  65. J Hypertens. 2008 Jan;26(1):117-23 - PubMed
  66. Mayo Clin Proc. 1999 Feb;74(2):126-30 - PubMed
  67. Hypertension. 1993 Aug;22(2):231-6 - PubMed
  68. Scott Med J. 2007 Aug;52(3):8-13 - PubMed
  69. Ann Emerg Med. 2002 Feb;39(2):131-8 - PubMed
  70. J Biol Chem. 1992 Jul 15;267(20):13928-32 - PubMed
  71. Histochem Cell Biol. 1998 Oct;110(4):335-57 - PubMed
  72. Kidney Int. 1994 Sep;46(3):744-7 - PubMed
  73. Am J Physiol. 1992 Oct;263(4 Pt 2):H1318-21 - PubMed
  74. Biochem Biophys Res Commun. 1989 Mar 31;159(3):1427-34 - PubMed
  75. Semin Nephrol. 1993 Jan;13(1):50-60 - PubMed
  76. Endocrinol Metab Clin North Am. 1995 Sep;24(3):481-509 - PubMed
  77. Circulation. 1993 Jul;88(1):82-91 - PubMed
  78. Biochem Biophys Res Commun. 1991 Aug 30;179(1):535-42 - PubMed
  79. Zhonghua Er Ke Za Zhi. 2006 Dec;44(12):886-90 - PubMed
  80. Int J Cardiol. 2009 Mar 20;133(1):51-4 - PubMed
  81. Clin Chem. 2006 Aug;52(8):1528-38 - PubMed
  82. Clin Exp Pharmacol Physiol. 1995 Jan;22(1):49-53 - PubMed
  83. N Engl J Med. 1998 Jul 30;339(5):321-8 - PubMed
  84. J Am Coll Cardiol. 2001 Feb;37(2):379-85 - PubMed
  85. N Engl J Med. 2011 Jul 7;365(1):32-43 - PubMed
  86. J Neuroimmunol. 1995 Mar;57(1-2):117-27 - PubMed
  87. J Cardiovasc Pharmacol. 1998;32 Suppl 3:S22-8 - PubMed

Publication Types